Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study

被引:13
|
作者
Maraki, Maria I. [1 ,2 ]
Yannakoulia, Mary [3 ]
Xiromerisiou, Georgia [4 ]
Stefanis, Leonidas [5 ,6 ]
Charisis, Sokratis [6 ,7 ]
Giagkou, Nikolaos [6 ]
Kosmidis, Mary H. [8 ]
Dardiotis, Efthimios
Hadjigeorgiou, Georgios M. [9 ]
Sakka, Paraskevi [10 ]
Scarmeas, Nikolaos [6 ,11 ]
Stamelou, Maria [6 ,12 ]
机构
[1] Hellen Mediterranean Univ, Sch Hlth Sci, Dept Nutr & Dietet, Iraklion 72300, Greece
[2] Natl & Kapodistrian Univ Athens, Sch Phys Educ & Sport Sci, Sect Sport Med & Biol Exercise, Athens, Greece
[3] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
[4] Univ Thessaly, Sch Med, Larisa, Greece
[5] Biomed Res Fdn Acad Athens, Ctr Clin Expt Surg & Translat Res, Athens, Greece
[6] Natl & Kapodistrian Univ Athens, Sch Med, Aiginit Hosp, Dept Neurol 1, 72 Vassilisis Sofias Ave, Athens 11528, Greece
[7] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA
[8] Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece
[9] Univ Cyprus, Med Sch, Dept Neurol, Nicosia, Cyprus
[10] Athens Assoc Alzheimers Dis & Related Disorders, Aiginit Hosp, Dept Neurol 1, 72 Vassilisis Sofias Ave, Athens 11528, Greece
[11] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Gertrude H Sergievsky Ctr, Dept Neurol, New York, NY 72300 USA
[12] HYGEIA Hosp, Parkinsons Dis & Movement Disorders Dept, Athens, Greece
关键词
elderly; Mediterranean; neurodegeneration; nutrition; prodromal; MDS RESEARCH CRITERIA; PATTERN; ADHERENCE; MARKERS; COHORT;
D O I
10.1111/ene.15698
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and purpose: Lifestyle factors have been implicated in the long-lasting neurodegenerative process in prodromal Parkinson's disease (pPD). The aim was to investigate the associations between adherence to a Mediterranean diet (MeDi) and longitudinal changes of pPD probability and the development of Parkinson's disease (PD) or pPD in a Mediterranean older population.Methods: Data from the Hellenic Longitudinal Investigation of Aging and Diet cohort (community-dwelling individuals, aged >= 65 years) were used. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate MeDi adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. The probability of pPD was calculated according to the updated Movement Disorder Society research criteria.Results: In all, 1047 non-PD/dementia with Lewy bodies (DLB) participants were followed for 3 +/- 1 years. MeDi adherence was associated with lower increase in pPD probability over time (b = -0.003, 95% confidence interval -0.006 to -0.001, p = 0.010). Forty-nine participants had incident possible/probable pPD (i.e., pPD probability >= 30%). Compared to the participants in the lowest quartile of MeDi adherence, those in the higher quartiles had an approximately 60%-70% lower risk for possible/probable pPD (p for trend 0.003). MeDi-pPD associations were driven by both motor and non-motor pPD markers and not from risk markers. Also, 21 participants were diagnosed with PD/DLB at follow-up. For each unit increase in the MeDi score, there was a 9%-10% lower risk for PD/DLB (hazard ratio 0.906 [95% confidence interval 0.823-0.997], p = 0.044).Conclusions: Mediterranean diet adherence is associated with lower increase in pPD probability over time and lower possible/probable pPD and PD/DLB incidence in older Mediterranean people. More studies are needed to confirm our results in other populations.
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页码:934 / 942
页数:9
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