Effects of genetic polymorphisms of LINC-PINT gene on liver cancer susceptibility in the Chinese Han population

被引：2
|
作者：
Yu, Zhiwei [1 ]
Li, Shizong [1 ]
Wang, Kaiqiong [1 ]
Gong, Dongwei [1 ]
Qiao, Xin [1 ]
Wu, Changxiong [1 ]
机构：
[1] Hainan Med Univ, Hainan Gen Hosp, Dept Hepatopancreatobiliary Surg, Hainan Affiliated Hosp, Haikou 570311, Peoples R China
来源：
FUTURE ONCOLOGY | 2023年 / 19卷 / 17期
关键词：
genetic risk; LINC-PINT; liver cancer; single nucleotide polymorphisms; RISK; METAANALYSIS; ASSOCIATION; PROGRESSION;
D O I：
10.2217/fon-2022-0669
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: Liver cancer (LC) is the most common cause of cancer mortality. This study aimed to explore the impact of LINC-PINT polymorphisms on LC. Materials & methods: The authors recruited 591 LC patients and 592 healthy controls. The association between LINC-PINT polymorphisms and susceptibility to LC was determined by logistic regression analysis. Results: The authors found that rs157916 and rs16873842 reduced susceptibility to LC. rs157916 decreased LC risk in patients aged <55 years, nondrinkers and those with BMI <24. rs16873842 had a protective role against LC in patients aged >= 55 years, women, nonsmokers and those with BMI >= 24. rs7801029 decreased LC risk in patients with BMI Conclusion: LINC-PINT polymorphisms exert a protective effect against LC.
引用
收藏
页码：1187 / 1195
页数：9
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