Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population

被引：4
|
作者：
Lu, Zhengmao [1 ]
Luo, Tianhang [1 ]
Nie, Mingming [1 ]
Bi, Jianwei [1 ]
Ke, Chongwei [1 ]
Xue, Xuchao [1 ]
Ma, Liye [1 ]
Fang, Guoen [1 ]
机构：
[1] Second Mil Med Univ, Dept Gen Surg, Changhai Hosp, Shanghai 200433, Peoples R China
来源：
BIOMARKERS | 2013年 / 18卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Cancer susceptibility; gastric cancer; genetic polymorphisms; molecular markers; risk factors; XRCC1; gene; DNA-REPAIR; RISK; ASSOCIATION; ARG399GLN; MORTALITY; EUROPE;
D O I：
10.3109/1354750X.2013.822562
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This study aims to evaluate whether the c.1471G>A and c.1686C>G genetic polymorphisms of XRCC1 gene influencing gastric cancer susceptibility. A total of 813 subjects with Chinese Han ethnicity were enrolled. Our data suggest that the allele and genotype frequencies are significantly different from gastric cancer patients with cancer-free controls. We find that c.1471G>A and c.1686C>G genetic polymorphisms statistically increase the risk of gastric cancer. Our findings indicate these two genetic polymorphisms are related with the susceptibility to gastric cancer, and could be used as molecular markers for detecting gastric cancer in Chinese Han ethnicity.
引用
收藏
页码：542 / 546
页数：5
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