Let's talk about sex: Mechanisms of neural sexual differentiation in Bilateria

被引：0

作者：

Roggenbuck, Emma C. ^{[1
]}

Hall, Elijah A. ^{[1
]}

Hanson, Isabel B. ^{[1
]}

Roby, Alyssa A. ^{[1
]}

Zhang, Katherine K. ^{[1
]}

Alkatib, Kyle A. ^{[1
]}

Carter, Joseph A. ^{[1
,2
]}

Clewner, Jarred E. ^{[1
]}

Gelfius, Anna L. ^{[1
]}

Gong, Shiyuan ^{[1
]}

Gordon, Finley R. ^{[1
,2
]}

Iseler, Jolene N. ^{[1
]}

Kotapati, Samhita ^{[1
]}

Li, Marilyn ^{[1
]}

Maysun, Areeba ^{[1
]}

Mccormick, Elise O. ^{[1
]}

Rastogi, Geetanjali ^{[1
]}

Sengupta, Srijani ^{[1
]}

Uzoma, Chantal U. ^{[1
]}

Wolkov, Madison A. ^{[1
]}

Clowney, E. Josephine ^{[2
,3
]}

机构：

[1] Univ Michigan, MCDB 464-Cellular Divers Sex Differentiat Brain, Ann Arbor, MI USA

[2] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Michigan Neurosci Inst Affiliate, Ann Arbor, MI USA

来源：

WIRES MECHANISMS OF DISEASE | 2024年 / 16卷 / 02期

关键词：

apoptosis; circuit evolution; comparative neuroscience; development; DMRT; doublesex; fruitless; hormones; mating behavior; sex differentiation; NAKED MOLE-RATS; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; GONADOTROPIN-INHIBITORY HORMONE; DETERMINATION GENE FRUITLESS; CAENORHABDITIS-ELEGANS MALE; ESTROGEN-RECEPTOR-ALPHA; FEMALE MARMOSET MONKEYS; PROTANDROUS BLACK PORGY; RFAMIDE-RELATED PEPTIDE; CENTRAL-NERVOUS-SYSTEM;

D O I：

10.1002/wsbm.1636

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In multicellular organisms, sexed gonads have evolved that facilitate release of sperm versus eggs, and bilaterian animals purposefully combine their gametes via mating behaviors. Distinct neural circuits have evolved that control these physically different mating events for animals producing eggs from ovaries versus sperm from testis. In this review, we will describe the developmental mechanisms that sexually differentiate neural circuits across three major clades of bilaterian animals-Ecdysozoa, Deuterosomia, and Lophotrochozoa. While many of the mechanisms inducing somatic and neuronal sex differentiation across these diverse organisms are clade-specific rather than evolutionarily conserved, we develop a common framework for considering the developmental logic of these events and the types of neuronal differences that produce sex-differentiated behaviors.This article is categorized under: Congenital Diseases > Stem Cells and Development Neurological Diseases > Stem Cells and Development

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