Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases

被引：2

作者：

Cheng, Xi-Xi ^{[1
,2
]}

Li, Ming-Qing ^{[3
,4
,5
]}

Peng, Ting ^{[1
,2
]}

机构：

[1] Shanghai Changning Matern & Infant Hlth Hosp, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Obstet & Gynecol Hosp, Dept Obstet, Shanghai 200080, Peoples R China

[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Inst Planned Parenthood Res, NHC Key Lab Reprod Regulat, Shanghai 200080, Peoples R China

[4] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai 200080, Peoples R China

[5] Fudan Univ, Hosp Obstet & Gynecol, Inst Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2024年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

prokineticin1; maternal-fetal interface; angiogenesis; recurrent miscarriage; preeclampsia; fetal growth restriction; ENDOTHELIAL-GROWTH-FACTOR; PROTEIN-COUPLED RECEPTORS; EG-VEGF; MOLECULAR CHARACTERIZATION; PORCINE ENDOMETRIUM; 1ST TRIMESTER; PPAR-GAMMA; CELL-LINE; EXPRESSION; GENE;

D O I：

10.7150/ijms.76817

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prokineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin signaling has been described in certain pathological states associated with pregnancy, including pre-eclampsia, recurrent miscarriage and fetal growth restriction. In this review, the expression and pleiotropic roles of PROK1 under physiological and pathological pregnancy conditions are discussed.

引用

页码：27 / 36

页数：10

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