High expression of interleukin-17A in cutaneous sarcoidosis

被引：0
|
作者：
Shimon, Stephanie, V [1 ,2 ]
Desai, Karishma [2 ]
Miteva, Mariya [2 ]
Nadji, Mehrdad [3 ]
Romanelli, Paolo [2 ]
机构：
[1] Nova Southeastern Univ, Coll Allopath Med, Ft Lauderdale, FL 33328 USA
[2] Univ Miami, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, Miami, FL USA
[3] Univ Miami Hlth Syst, Dept Clin Pathol, Miami, FL USA
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 190卷 / 03期
关键词：
T-CELLS; IL-17; TH17;
D O I：
10.1093/bjd/ljad438
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Increasing evidence of Th17 pathways is implicated in sarcoidosis granulomatous inflammation and maintenance. Our study evaluated the presence of IL-17A, a downstream proinflammatory cytokine, in cutaneous sarcoidosis biopsies. We found that all 26 biopsy samples had increased expression of IL-17A, predominantly located in macrophages within granulomas, in the cytoplasm of multinucleated histiocytes surrounding the granulomas and within lymphocytic infiltrates surrounding the inflammation.
引用
收藏
页码：434 / 436
页数：3
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