High expression of interleukin-17A in cutaneous sarcoidosis

被引：0

作者：

Shimon, Stephanie, V ^{[1
,2
]}

Desai, Karishma ^{[2
]}

Miteva, Mariya ^{[2
]}

Nadji, Mehrdad ^{[3
]}

Romanelli, Paolo ^{[2
]}

机构：

[1] Nova Southeastern Univ, Coll Allopath Med, Ft Lauderdale, FL 33328 USA

[2] Univ Miami, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, Miami, FL USA

[3] Univ Miami Hlth Syst, Dept Clin Pathol, Miami, FL USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 190卷 / 03期

关键词：

T-CELLS; IL-17; TH17;

D O I：

10.1093/bjd/ljad438

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Increasing evidence of Th17 pathways is implicated in sarcoidosis granulomatous inflammation and maintenance. Our study evaluated the presence of IL-17A, a downstream proinflammatory cytokine, in cutaneous sarcoidosis biopsies. We found that all 26 biopsy samples had increased expression of IL-17A, predominantly located in macrophages within granulomas, in the cytoplasm of multinucleated histiocytes surrounding the granulomas and within lymphocytic infiltrates surrounding the inflammation.

引用

页码：434 / 436

页数：3

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