Here, results are presented on the focusing of 1 mu m polystyrene particle suspensions using a synchronous oscillatory pressure-driven flow and oscillatory electric field in a microfluidic device. The effect of the phase difference between the oscillatory fields on the focusing position and focusing efficiency was investigated. The focusing position of negatively charged polystyrene particles could be tuned anywhere between the channel centerline to the channel walls. Similarly, the focusing efficiency could range from 20% up to 90%, depending on the phase difference, for particle Reynolds numbers of order O(10(-4)). The migration velocity profile was measured and the peak velocity was found to scale linearly with both the oscillatory pressure-driven flow amplitude and oscillatory electric field amplitude. Furthermore, the average migration velocity was observed to scale with the cosine of the phase difference between the fields, indicating the coupled non-linear nature of the phenomenon. Lastly, the peak migration velocity was measured for different particle radii and found to have an inverse relation, where the velocity increased with decreasing particle radius for identical conditions.
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Masaeli, Mahdokht
Sollier, Elodie
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Sollier, Elodie
Amini, Hamed
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Amini, Hamed
Mao, Wenbin
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Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Mao, Wenbin
Camacho, Kathryn
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Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Camacho, Kathryn
Doshi, Nishit
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Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Doshi, Nishit
Mitragotri, Samir
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Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Mitragotri, Samir
Alexeev, Alexander
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Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Alexeev, Alexander
Di Carlo, Dino
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
机构:
Zhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Tu, Chunglong
Zhou, Jian
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Zhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhou, Jian
Liang, Yitao
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h-index: 0
机构:
Zhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Liang, Yitao
Huang, Bobo
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机构:
Zhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Huang, Bobo
Fang, Yifeng
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机构:
Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Fang, Yifeng
Liang, Xiao
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Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Liang, Xiao
Ye, Xuesong
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机构:
Zhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, Dept Biomed Engn, Hangzhou 310027, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ, Minist Educ, Key Lab BME, Biosensor Natl Special Lab, Hangzhou 310027, Zhejiang, Peoples R China