Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline

被引：0
|
作者：
Acevedo, Deiby F. Aparicio [1 ]
Villamizar, Marlyn C. Ortiz [1 ]
Kouznetsov, Vladimir V. [1 ]
机构：
[1] Univ Ind Santander, Escuela Quim, Lab Quim Organ & Biomol, Cl 9 Cra 27, Bucaramanga 680006, Colombia
来源：
MOLBANK | 2024年 / 2024卷 / 01期
关键词：
4,7-dichloroquinoline; N-oxides; C-H bond functionalization; C2-amide formation reaction; C4 SNAr reaction; N-(quinolinyl)morpholines; N-(quinolinyl)amides; Lipinski's descriptors; QUINOLINE N-OXIDES; DESIGN; IDENTIFICATION; FUNCTIONALIZATION; CHEMISTRY;
D O I：
10.3390/M1796
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a N-oxidation reaction/C2-amide formation reaction/C4 SNAr reaction sequence. The structure of the compound was fully characterized by FT-IR, 1H-, C-13-NMR, DEPT-135(degrees), and ESI-MS techniques. Its physicochemical parameters (Lipinski's descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic properties.
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页数：8
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