Predictive factors of spontaneous pregnancies among women with diminished ovarian reserve patients treated with DHEA

Introduction. - Diminished ovarian reserve remains a challenge in the reproductive medicine field. Treatment options for these patients are limited and there is no consensus to make any recommendations. Regarding adjuvant supplements, DHEA could play a role in follicular recruitment and, therefore, may increase spontaneous pregnancy rate.Materials and methods. - This study was a monocentric historical and observational cohort study carried out in the reproductive medicine department at the University Hospital, Femme-Mere-Enfant in Lyon. All women presenting with a diminished ovarian reserve treated with 75 mg/day of DHEA were consecutively included. The main objective was to evaluate the spontaneous pregnancy rate. The secondary objectives were to identify predictive factors for pregnancy and the evaluation of treatment side effects.Results. - Four hundred and thirty-nine women were included. In all, 277 were analyzed, 59 had a spontaneous pregnancy (21.3%). The probability of being pregnant was respectively 13.2% (IC95 9- 17.2%), 21.3% (IC95 15.1-27%) and 38.8% (IC95 29.3-48.4%) at 6, 12 and 24 months. Only 20.6% of patients complained of side effects.Conclusion. - DHEA may improve spontaneous pregnancies in women with diminished ovarian reserve without any stimulation. (c) 2023 Elsevier Masson SAS. All rights reserved.