Tumor immunity portrait: An AI-driven molecular predictor combining tumor microenvironment and tumor mutational burden for immune checkpoint inhibitor response prediction

被引:0
|
作者
Shilo, Polina [1 ]
Tarasov, Artem [1 ]
Filatova, Anna [1 ]
Danilov, Konstantin [1 ]
Valiev, Ivan [1 ]
Kotlov, Nikita [1 ]
Brown, Jessica H. [1 ]
Ogloblina, Anna [1 ]
Bagaev, Alexander [1 ]
Fowler, Nathan [1 ]
机构
[1] BostonGene Corp, Waltham, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e14691
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
    Naoki Shinojima
    Kazutaka Ozono
    Haruaki Yamamoto
    Sakiko Abe
    Rumi Sasaki
    Yusuke Tomita
    Azusa Kai
    Ryosuke Mori
    Takahiro Yamamoto
    Ken Uekawa
    Hirotaka Matsui
    Kisato Nosaka
    Hiroaki Matsuzaki
    Yoshihiro Komohara
    Yoshiki Mikami
    Akitake Mukasa
    [J]. Brain Tumor Pathology, 2023, 40 : 185 - 190
  • [42] Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer
    Schrock, A. B.
    Ouyang, C.
    Sandhu, J.
    Sokol, E.
    Jin, D.
    Ross, J. S.
    Miller, A.
    Lim, D.
    Amanam, I
    Chao, J.
    Catenacci, D.
    Cho, M.
    Braiteh, F.
    Klempner, S. J.
    Ali, S. M.
    Fakih, M.
    [J]. ANNALS OF ONCOLOGY, 2019, 30 (07) : 1096 - 1103
  • [43] Combined Assessment of the Tumor-Stroma Ratio and Tumor Immune Cell Infiltrate for Immune Checkpoint Inhibitor Therapy Response Prediction in Colon Cancer
    Ravensbergen, Cor J.
    Polack, Meaghan
    Roelands, Jessica
    Crobach, Stijn
    Putter, Hein
    Gelderblom, Hans
    Tollenaar, Rob A. E. M.
    Mesker, Wilma E.
    [J]. CELLS, 2021, 10 (11)
  • [44] Circulating Tumor DNA Mutant Allele Frequency and Tumor Burden as Biomarkers for Response to Immune Checkpoint Blockade
    Chae, Y. K.
    Davis, A.
    Agte, S.
    Pan, A.
    Mohindra, N.
    Villaflor, V.
    Giles, F.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S1762 - S1762
  • [45] Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
    Fu, Tong
    Dai, Lei-Jie
    Wu, Song-Yang
    Xiao, Yi
    Ma, Ding
    Jiang, Yi-Zhou
    Shao, Zhi-Ming
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [46] Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
    Tong Fu
    Lei-Jie Dai
    Song-Yang Wu
    Yi Xiao
    Ding Ma
    Yi-Zhou Jiang
    Zhi-Ming Shao
    [J]. Journal of Hematology & Oncology, 14
  • [47] Tumor Immune Microenvironment Associates with Treatment Response to Immune Checkpoint Therapy (ICT) in Mesothelioma
    Li, Huihua
    Mitchell, Owen
    Jameel, Rohail
    Mueller, Jeffrey
    Husain, Aliya
    [J]. LABORATORY INVESTIGATION, 2023, 103 (03) : S1642 - S1643
  • [48] DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden
    Hsiehchen, David
    Hsieh, Antony
    Samstein, Robert M.
    Lu, Tianshi
    Beg, Muhammad S.
    Gerber, David E.
    Wang, Tao
    Morris, Luc G. T.
    Zhu, Hao
    [J]. CELL REPORTS MEDICINE, 2020, 1 (03)
  • [49] Mutational burden, tumor immune checkpoint expression, and microsatellite instability in gynecologic malignancies: Implications for immune therapy
    Winer, I.
    Jones, N. L.
    Xiu, J.
    Ellerbrock, A.
    Brown, J.
    Herzog, T.
    [J]. GYNECOLOGIC ONCOLOGY, 2018, 149 : 45 - 45
  • [50] Using tumor immune microenvironment physiologic profiling to tailor immune checkpoint inhibitor diagnostic classification
    Seitz, Robert S.
    Ring, Brian Z.
    Cronister, Catherine T.
    Ross, Douglas T.
    Schweitzer, Brock
    [J]. CANCER RESEARCH, 2023, 83 (07)