CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis: 2022 addendum

被引：8

作者：

Turgeon, David ^{[1
]}

Bakowsky, Volodko ^{[2
]}

Baldwin, Corisande ^{[3
]}

Cabral, David A. ^{[4
]}

Clements-Baker, Marie ^{[5
]}

Clifford, Alison ^{[6
]}

Tervaert, Jan Willem Cohen ^{[6
]}

Dehghan, Natasha ^{[3
]}

Ennis, Daniel ^{[3
]}

Famorca, Leilani ^{[7
]}

Fifi-Mah, Aurore ^{[8
]}

Girard, Louis-Philippe ^{[9
]}

Lefebvre, Frederic ^{[10
]}

Liang, Patrick ^{[11
]}

Makhzoum, Jean-Paul ^{[12
]}

Massicotte-Azarniouch, David ^{[13
,14
]}

Mendel, Arielle ^{[15
]}

Milman, Nataliya ^{[16
]}

Reich, Heather N. ^{[17
]}

Robinson, David B. ^{[18
]}

Ross, Carolyn ^{[12
]}

Rumsey, Dax G. ^{[19
]}

Soowamber, Medha ^{[1
]}

Towheed, Tanveer E. ^{[5
]}

Trudeau, Judith ^{[20
]}

Twilt, Marinka ^{[21
]}

Yacyshyn, Elaine ^{[6
]}

Yardimci, Gozde K. ^{[1
]}

Khalidi, Nader ^{[7
]}

Barra, Lillian ^{[22
]}

Pagnoux, Christian ^{[1
]}

机构：

[1] Univ Toronto, Mt Sinai Hosp, Div Rheumatol, Vasculitis Clin, Toronto, ON, Canada

[2] Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Div Rheumatol, Halifax, NS, Canada

[3] Univ British Columbia, Div Rheumatol, Vancouver, BC, Canada

[4] Univ British Columbia, BC Childrens Hosp, Div Pediat Rheumatol, Vancouver, BC, Canada

[5] Queens Univ, Div Rheumatol, Kingston, ON, Canada

[6] Univ Alberta, Div Rheumatol, Edmonton, AB, Canada

[7] McMaster Univ, Div Rheumatol, Hamilton, ON, Canada

[8] Univ Calgary, Div Rheumatol, Calgary, AB, Canada

[9] Univ Calgary, Div Nephrol, Calgary, AB, Canada

[10] Univ Montreal, Ctr Hosp Univ Montreal, Div Rheumatol, Montreal, PQ, Canada

[11] Univ Sherbrooke, Ctr Hosp Univ Sherbrooke, Div Rheumatol, Sherbrooke, PQ, Canada

[12] Univ Montreal, Hop Sacre Coeur Montreal, Div Internal Med, Montreal, PQ, Canada

[13] Univ Ottawa, Ottawa Hosp, Div Nephrol, Ottawa, ON, Canada

[14] Ottawa Hosp Res Inst, Ottawa, ON, Canada

[15] McGill Univ, Div Rheumatol, Hlth Ctr, Montreal, PQ, Canada

[16] Univ Ottawa, Ottawa Hosp, Div Rheumatol, Ottawa, ON, Canada

[17] Univ Toronto, Univ Hlth Network, Div Nephrol, Toronto, ON, Canada

[18] Univ Manitoba, Div Rheumatol, Winnipeg, MB, Canada

[19] Univ Alberta, Dept Pediat, Div Pediat Rheumatol, Edmonton, AB, Canada

[20] Univ Laval, Div Rheumatol, CISSS Chaudiere Appalaches, Quebec City, PQ, Canada

[21] Univ Calgary, Alberta Childrens Hosp, Dept Pediat, Div Pediat Rheumatol, Calgary, AB, Canada

[22] Western Univ, Dept Med, Div Rheumatol, London, ON, Canada

来源：

RHEUMATOLOGY | 2023年 / 62卷 / 08期

关键词：

ANCA; anti-neutrophil cytoplasm antibody-associated vasculitis; granulomatosis with polyangiitis; microscopic polyangiitis; glomerulonephritis; avacopan; ANCA-ASSOCIATED VASCULITIS; REMISSION INDUCTION; GLUCOCORTICOIDS; CYCLOPHOSPHAMIDE; MANAGEMENT; RITUXIMAB; MORTALITY; PROTECTS;

D O I：

10.1093/rheumatology/kead087

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of ANCA-associated vasculitides (AAV). The current addendum provides further recommendations regarding the use of avacopan in AAV based on a review of newly available evidence. Methods An updated systematic literature review on avacopan (formerly, CCX168) using Medline, Embase, and the Cochrane Library was performed for publications up to September 2022. New recommendations were developed and categorized according to the EULAR grading levels, as done for previous CanVasc recommendations. A modified Delphi procedure and videoconferences were used to reach >= 80% consensus on the inclusion, wording and grading of each recommendation. Results Three new recommendations were developed. They focus on avacopan therapy indication and duration, as well as timely glucocorticoid tapering. Conclusion These 2022 addended recommendations provide rheumatologists, nephrologists and other specialists caring for patients with AAV with guidance for the use of avacopan, based on current evidence and consensus from Canadian experts.

引用

页码：2646 / 2651

页数：6

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