MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation

被引：9
|
作者：
Peuget, Sylvain [1 ]
Selivanova, Galina [1 ,2 ]
机构：
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
[2] Karolinska Inst, Biomedicum C8,Solnavagen 9, S-17165 Stockholm, Sweden
来源：
CANCER DISCOVERY | 2023年 / 13卷 / 05期
关键词：
D O I：
10.1158/2159-8290.CD-23-0229
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Discovery , Adams and colleagues present the discovery of a potent PROTAC, MDM2 degrader, which activates wild-type p53 leading to cancer cell death. Importantly, in a number of in vitro and in vivo experiments, the authors show that the depletion of MDM2 by PROTAC kills p53-mutant or p53-null cancer cells.
引用
收藏
页码：1043 / 1045
页数：3
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