Mpox vaccination and treatment: a systematic review

被引：2

作者：

Eslami, Arvin ^{[1
]}

Alimoghadam, Shaya ^{[1
]}

Khoshravesh, Sahar ^{[1
]}

Shiriani, Mahsa ^{[1
]}

Alimoghadam, Rojina ^{[1
]}

Darazam, Ilad Alavi ^{[2
,3
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Infect Dis & Trop Med Res Ctr, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Infect Dis, Tehran, Iran

来源：

JOURNAL OF CHEMOTHERAPY | 2024年 / 36卷 / 02期

关键词：

Monkeypox; mPV; mPXV; pre-exposure; post-exposure; mpox; MODIFIED VACCINIA ANKARA; ATTENUATED SMALLPOX VACCINE; PROTECTS NONHUMAN-PRIMATES; LONG-TERM PROTECTION; MONKEYPOX VIRUS; JYNNEOS VACCINE; UNITED-STATES; SAFETY; IMMUNOGENICITY; ACAM2000;

D O I：

10.1080/1120009X.2023.2289270

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analysis highlights Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN)'s potential, though efficacy concerns exist. Tecovirimat emerged as a prominent antiviral in the recent outbreak. However, limited evidence underscores the imperative for further clinical trials in understanding and managing monkeypox.

引用

页码：85 / 109

页数：25

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