Thermo-sensitive injectable hydrogel loading with elemene-loaded liposomes for enhanced anti-tumor effect

被引：3

作者：

Li, Yijing ^{[1
]}

Zhu, Yanhui ^{[1
]}

Chen, Jiaqi ^{[1
]}

Wang, Huahua ^{[1
]}

Zhi, Weiwei ^{[1
]}

Wang, Ziang ^{[1
]}

Guan, Yanbin ^{[1
]}

Wang, Baiyan ^{[2
]}

Jia, Yongyan ^{[1
]}

Huang, Shengnan ^{[3
,5
]}

Zhu, Xiali ^{[1
,4
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou, Peoples R China

[2] Henan Univ Chinese Med, Sch Basic Med, Zhengzhou, Peoples R China

[3] Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou, Peoples R China

[4] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[5] Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou 450046, Peoples R China

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2023年 / 37卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Combined therapy; thermo-sensitive hydrogel; liposomes; elemene; nano graphene oxide; glycyrrhetinic acid; DRUG-DELIVERY; BETA-ELEMENE; CANCER; GEL; NANOPARTICLES; INJECTION; THERAPY; CELLS; OXIDE; MICE;

D O I：

10.1177/08853282231172837

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Due to the heterogeneity and the complexity of the tumor microenvironment, combination therapy, especially the combination of chemotherapy and photothermal therapy (PTT), had received increasing attention. However, the co-delivery of small molecule drugs for chemotherapy and photothermal agents was a key issue. Herein, we prepared a novel thermo-sensitive hydrogel loading with elemene (ELE)-loaded and nano graphene oxide (NGO)-based liposomes for enhanced combined therapy. ELE was applied as the model drug for chemotherapy because it was a natural sesquiterpene drug with broad-spectrum and efficient antitumor activity. NGO was applied as drug carrier and photothermal agent simultaneously due to its two-dimensional structure and high photo-thermal conversion efficacy. NGO was further modified with glycyrrhetinic acid (GA) to improve its water dispersion, biocompatibility and tumor-targeting ability. ELE was loaded by GA-modified NGO (GA/NGO) to prepare the liposomes designated as ELE-GA/NGO-Lip, which was further mixed with chitosan (CS) solution and beta-glycerin sodium phosphate (beta-GP) solution to prepare the thermo-sensitive hydrogel designated as ELE-GA/NGO-Lip-gel. The obtained ELE-GA/NGO-Lip-gel had the gelling temperature of 37 degrees C, temperature and pH-response gel dissolution and high photo-thermal conversion effect. More importantly, ELE-GA/NGO-Lip-gel upon 808 nm laser irradiation had relative high anti-tumor efficiency against SMMC-7721 cells in vitro. This research might provide a potent platform for the application of thermos-sensitive injectable hydrogel in combined tumor therapy.

引用

页码：1847 / 1857

页数：11