Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives

被引：22

作者：

Yang, Zuguang ^{[1
]}

Wei, Guangming ^{[1
]}

Chen, Zhengkai ^{[1
]}

Wu, Xiao-Feng ^{[2
,3
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China

[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 33期

关键词：

85;

D O I：

10.1039/d3cc00836c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF3-imidoyl sulfoxonium ylides (TFISYs), are systematically summarized and discussed. The cascade annulation reactions of trifluoromethyl-containing synthons with suitable coupling partners have emerged as a powerful and promising tool for the construction of a variety of trifluoromethyl-substituted heterocycles. Compared with other trifluoromethyl-containing building blocks, TFAICs and derivatives have notable merits of easy availability and handling, relative stability and safety, and high reactivity.

引用

页码：4872 / 4890

页数：19

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