Temporal analysis of remote electric neuromodulation for the prevention of migraine

被引：2

作者：

Blumenfeld, Andrew M. ^{[1
,2
]}

Rabany, Liron ^{[3
]}

Ironi, Alon ^{[3
]}

Stark-Inbar, Alit ^{[3
]}

Harris, Dagan ^{[3
]}

Singh, Rashmi B. Halker ^{[4
]}

Harriott, Andrea M. ^{[5
]}

机构：

[1] Los Angeles Headache Ctr, Los Angeles, CA 90067 USA

[2] San Diego Headache Ctr, San Diego, CA 92111 USA

[3] Theran Bioelect, IL-4250438 Netanya, Israel

[4] Mayo Clin, Scottsdale, AZ 85259 USA

[5] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

PAIN MANAGEMENT | 2023年 / 13卷 / 08期

关键词：

headache; migraine; neuromodulation; nerivio; prevention; prophylaxis; remote electric neuromodulation; REN; treatment; timing; PREFERENCES;

D O I：

10.2217/pmt-2023-0039

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: To evaluate the onset, magnitude and persistence of efficacy of remote electrical neuromodulation (REN) compared with placebo for the preventive treatment of migraine. Materials & methods: Analysis was conducted on data from a prospective, double-blind, placebo-controlled clinical trial, which assessed the efficacy of REN for the prevention of migraine. The number of monthly migraine days (MMD) per group was calculated in 2-week intervals and compared between the groups. Results: Differences between the active (N = 95) and placebo (N = 84) groups reached significance at 2 weeks: therapeutic gain 0.84 MMD, p = 0.036. Four weeks gain 1.59 MMD; p = 0.025, 6 weeks gain 2.27 MMD; p < 0.001, 8 weeks gain 2.68 MMD; p < 0.001. Conclusion: REN provides rapid and consistent efficacy in preventive treatment of migraine.

引用

页码：425 / 432

页数：8

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