Modeling Tauopathies in Zebrafish (Danio rerio)

被引：0

作者：

Kotova, M. M. ^{[1
]}

Kolesnikova, T. O. ^{[1
]}

Kalueff, A. V. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Sirius Univ Sci & Technol, Div Neurobiol, Town settlement Sirius, Sirius, Russia

[2] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia

[3] Ural Fed Univ, Ekaterinburg, Russia

[4] Almazov Natl Med Res Ctr, St Petersburg, Russia

[5] Granov Russian Res Ctr Radiol & Surg Technol, St Petersburg, Russia

来源：

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2023年 / 59卷 / 06期

关键词：

zebrafish; taupathies; animal model; neurodegeneration; tau protein; PROGRESSIVE SUPRANUCLEAR PALSY; GLYCOGEN-SYNTHASE KINASE-3; ALZHEIMER-DISEASE; TAU; PROTEIN; MICROTUBULE; NEURODEGENERATION; AUTOPHAGY; ACID;

D O I：

10.1134/S0022093023060133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer's disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish (Danio rerio), as well as outline novel research trends in this field.

引用

页码：2055 / 2071

页数：17

共 50 条

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