Given the human, industrial and societal costs of Musculoskeletal Disorders (MSDs) we evaluated antecedents to MSDs (assessed as pain, doctor diagnosis, and workplace injury) over a six-year period T1 (2014/2015) and T2 (2020/2021). The purpose of the study was to examine the role of We proposed that the the organisational climate (i.e., psychosocial safety climate, PSC) for employees' psychological health and safety is as an antecedent to physical demands, and psychosocial risks (e.g., low control, harassment) that in turn might relate to MSDs using a longitudinal design. Thus, we aimed to discourse the shortage of longitudinal investigations of the MSDs, causation and the role of corporate climate and psychosocial risk factors. We used matched data from follow-up telephone interviews of 432 Australian employees. We found evidence for several psychosocial paths; PSC was related to future workplace injuries through decision authority; PSC was related to MSD pain through depressive symptoms. For future doctor diagnosed MSDs, PSC was directly negatively related. Older age, being male and low income was related to work injury; being female associated with MSD pain; and being older was associated with MSD diagnosis. A novel finding was the linkage between psychosocial risks (low skill discretion and harassment) and future physical demands leading to future MSD pain and work injury highlighting a new pathways (mechanism) mechanism -linking how psychosocial mechanisms relate toand physical mechanismsaspects. Overall poor PSC was found as a distal antecedent of all MSDs. Decision authority and skill discretion were most critical psychosocial risks in predicting future pain and injuries. Psychosocial factors predicted future demands. Actions should target improving PSC and autonomy and reducing harassment and physical demands, to decrease the incidence of MSDs.