Synthesis of functionalized sulfilimines via iron-catalyzed sulfur alkylation of sulfenamides with diazo compounds

被引：13
|
作者：
Wu, Xianda [1 ,2 ]
Chen, Minghong [1 ,2 ]
He, Fu-Sheng [1 ,2 ]
Wu, Jie [1 ,2 ,3 ,4 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Jiaojiang 318000, Zhejiang, Peoples R China
[2] Taizhou Univ, Inst Adv Studies, Jiaojiang 318000, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
来源：
GREEN CHEMISTRY | 2023年 / 25卷 / 22期
基金：
中国国家自然科学基金;
关键词：
CONTAINING PHARMACEUTICALS; NATURAL-PRODUCTS; TRIFLUOROMETHYLATION; FLUORINE; ACCESS; CYCLOADDITION; SULFIDES;
D O I：
10.1039/d3gc03528j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient iron-catalyzed sulfur alkylation of sulfenamides with 2,2,2-trifluorodiazoethane is developed. The reaction proceeds smoothly at room temperature in an open flask, enabling the rapid synthesis of trifluoromethylated sulfilimines in moderate to good yields with broad functional group tolerance. In addition, this operationally simple protocol could also be applied to access cyano- and phosphonyl-functionalized sulfilimines using diazoacetonitrile or diazomethylphosphonate.
引用
收藏
页码：9092 / 9096
页数：5
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