The discovery of orbital angular momentum (OAM) for the last three decades has made it very versatile for an extensive range of applications. It is an imperative tool for optical research community. So, in this study, we investigated the interaction of vortex electromagnetic (VEM) wave with a perfect electromagnetic conductor (PEMC) sphere. The PEMC is regarded as an extension of the perfect electric and the perfect magnetic conductors. The incident VEM wave fields are expanded by taking into account features of OAM and using spherical vector wave functions (SVWFs). The incident expansion coefficients for VEM wave are derived by means of the definite integrals. Various factors such as normalized differential scattering cross section (DSCS), OAM density, total time-averaged intensity and total field intensity in the context of the electric field amplitudes for scattered fields are computed and investigated. It is expected that findings of the study would be beneficial regarding interaction between the VEM waves and metamaterials in terms of optical diagnostics, optical tweezers and manipulation of spherical particles/surfaces. Findings from this study have applications in electromagnetic scattering and propagation, OAM imaging, particle characterization, measuring optical radiation force, radiative transfer processes, scattering asymmetry factor, remote sensing, radar technology, telecommunications systems and other domains. OAM density (linear + circular), total time-averaged intensity, total scattered electric field intensity and normalized DSCS have also been analyzed numerically. The influence of sphere size, beam waist radius and electromagnetic admittance is examined and discussed.