Multi-scale numerical simulation on mechano-transduction of osteocytes in different gravity fields

被引：4
|
作者：
Zhao, Chaohui [1 ,2 ]
Liu, Haiying [1 ,2 ]
Tian, Congbiao [1 ,2 ]
Zhang, Chunqiu [1 ,2 ]
Wang, Wei [3 ]
机构：
[1] Tianjin Univ Technol, Sch Mech Engn, Tianjin Key Lab Adv Mechatron Syst Design & Intel, Tianjin, Peoples R China
[2] Tianjin Univ Technol, Natl Demonstrat Ctr Expt Mech & Elect Engn Educ, Tianjin, Peoples R China
[3] Tianjin Univ, Sch Mech Engn, Dept Mech, Tianjin, Peoples R China
来源：
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING | 2023年 / 26卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Microgravity; lacunae-osteocyte system; amplification coefficient; osteocyte process; tethering elements; PRIMARY CILIUM; BONE-CELLS; NITRIC-OXIDE; MICROGRAVITY; MODEL;
D O I：
10.1080/10255842.2022.2117552
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
A three-dimensional model for osteocyte was established to research the mechanisms of mechano-transduction and amplification of primary cilium and osteocyte process in every gravity field. The results showed that significant stress concentration was observed in the area of physical connection between TES and the osteocyte process, where the fluid shear stress (FSS) was around two orders of magnitude higher than that in other areas. Due to the significant amplification effect of the TES structure on mechanical stimulation, making osteocyte process the "optimal mechanical receptor". In microgravity, the mechanical signal conduction ability of the osteocyte decreased significantly..
引用
收藏
页码：1419 / 1430
页数：12
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