The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect

被引：9

作者：

Rasmi, Yousef ^{[1
]}

Jalali, Ladan ^{[1
,8
]}

Khalid, Saliha ^{[2
]}

Shokati, Ameneh ^{[3
,4
]}

Tyagi, Poonam ^{[5
]}

Ozturk, Alpaslan ^{[6
]}

Nasimfar, Amir ^{[7
]}

机构：

[1] Urmia Univ Med Sci, Fac Med, Dept Biochem, Orumiyeh, Iran

[2] Kadir Has Univ, Sch Engn & Nat Sci, Dept Bioinformat & Genet, Cibali Campus Fatih, TR-34083 Istanbul, Turkiye

[3] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran

[4] Univ Tehran Med Sci, Neurosci Inst, Multiple Sclerosis Res Ctr, Tehran, Iran

[5] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh, Saudi Arabia

[6] Hlth Sci Univ, Ankara Diskapi Yildirim Beyazit Training & Res Hos, Dept Med Biochem, Ankara, Turkiye

[7] Urmia Univ Med Sci, Fac Med, Dept Pediat, Orumiyeh, Iran

[8] Urmia Univ Med Sci, Sch Med, Dept Biochem, Orumiyeh, Iran

来源：

CYTOKINE | 2023年 / 169卷

关键词：

Prolactin; SARS-CoV-2; Severity; COVID-19; Immunomodulatory effects; NECROSIS-FACTOR-ALPHA; ACTIVATED MACROPHAGES; SIGNAL-TRANSDUCTION; GROWTH-HORMONE; C-JUN; EXPRESSION; CELL; RECEPTOR; MECHANISMS; RELEASE;

D O I：

10.1016/j.cyto.2023.156253

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prolactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.

引用

页数：8

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