Catalytic Enantioselective [3+2] Cycloaddition of N-Metalated Azomethine Ylides

被引：21

作者：

Kumar, Sundaravel Vivek ^{[1
]}

Guiry, Patrick J. ^{[1
]}

机构：

[1] Univ Coll Dublin UCD Belfield, Ctr Synth & Chem Biol CSCB, Sch Chem, Dublin, Ireland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 28期

关键词：

asymmetric catalysis; azomethine ylide; 3+2] cycloaddition; 1,3-dipolar cycloaddition; pyrrolidines; ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; PHOSPHINAMINE LIGANDS; PYRROLIDINE; PROLINE; TRANS-2,5-DIALKYLPYRROLIDINYL-BENZYLDIPHENYLPHOSPHINES; DERIVATIVES; COMPLEXES; STRATEGY; ALKENES;

D O I：

10.1002/chem.202300296

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric [3+2] cycloaddition reactions are fascinating and powerful methods for the synthesis of enantioenriched pyrrolidines up to four stereocentres. Pyrrolidines are important compounds for both biology and organocatalytic applications. This review summarizes the most recent advances in the enantioselective synthesis of pyrrolidines by [3+2] cycloadditions of azomethine ylides using metal catalysis. It has been organized by the type of metal catalysis used and further arranged by the complexity nature of dipolarophile. The presentation of each reaction type highlights their advantages and limitations.

引用

页数：18

共 50 条

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