Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection
被引:17
|
作者:
Hedstrom, Anna Karin
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Stockholm, SwedenKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Hedstrom, Anna Karin
[1
]
机构:
[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
来源:
FRONTIERS IN IMMUNOLOGY
|
2023年
/
14卷
关键词:
multiple sclerosis;
Epstein-Barr virus;
infectious mononucleosis;
human leukocyte antigen;
vitamin D;
sun exposure;
smoking;
obesity;
VITAMIN-D STATUS;
BODY-MASS INDEX;
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;
NATURAL-KILLER-CELLS;
T-CELLS;
IMMUNE-RESPONSE;
CYTOMEGALOVIRUS-SEROPOSITIVITY;
ANTIBODY-TITERS;
TOBACCO-SMOKE;
SUN EXPOSURE;
D O I:
10.3389/fimmu.2023.1212676
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented.
机构:
Stanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USAStanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA
Robinson, William H.
Steinman, Lawrence
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机构:
Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USAStanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA
机构:
Rockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, Lab Viral Immunobiol, New York, NY 10021 USARockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, Lab Viral Immunobiol, New York, NY 10021 USA
Lunemann, Jan D.
Munz, Christian
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h-index: 0
机构:
Rockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, Lab Viral Immunobiol, New York, NY 10021 USARockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, Lab Viral Immunobiol, New York, NY 10021 USA
机构:
Louisiana State Univ, Hlth Sci Ctr, Dept Neurol, New Orleans, LA 70112 USALouisiana State Univ, Hlth Sci Ctr, Dept Neurol, New Orleans, LA 70112 USA
机构:
Univ Roma La Sapienza, Dept Neurol, S Andrea Hosp, Rome, Italy
Univ Roma La Sapienza, Ctr Expt Neurol Therapy, S Andrea Hosp, Rome, ItalyIst Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
Salvetti, Marco
Giovannoni, Gavin
论文数: 0引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London, EnglandIst Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
Giovannoni, Gavin
Aloisi, Francesca
论文数: 0引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, ItalyIst Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy