Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection

被引:17
|
作者
Hedstrom, Anna Karin [1 ]
机构
[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
multiple sclerosis; Epstein-Barr virus; infectious mononucleosis; human leukocyte antigen; vitamin D; sun exposure; smoking; obesity; VITAMIN-D STATUS; BODY-MASS INDEX; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NATURAL-KILLER-CELLS; T-CELLS; IMMUNE-RESPONSE; CYTOMEGALOVIRUS-SEROPOSITIVITY; ANTIBODY-TITERS; TOBACCO-SMOKE; SUN EXPOSURE;
D O I
10.3389/fimmu.2023.1212676
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented.
引用
收藏
页数:13
相关论文
共 50 条
  • [21] Epstein-barr virus in multiple sclerosis
    Bridget A. Bagert
    Current Neurology and Neuroscience Reports, 2009, 9 : 405 - 410
  • [22] Epstein-Barr virus and multiple sclerosis
    Robinson, William H.
    Steinman, Lawrence
    SCIENCE, 2022, 375 (6578) : 264 - 265
  • [23] Epstein-Barr virus and multiple sclerosis
    Ascherio, A
    Munch, M
    EPIDEMIOLOGY, 2000, 11 (02) : 220 - 224
  • [24] Epstein-Barr virus and multiple sclerosis
    Lunemann, Jan D.
    Munz, Christian
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2007, 7 (03) : 253 - 258
  • [25] Epstein-Barr virus and multiple sclerosis
    Skliar, A., I
    Torianyk, I. I.
    Osolodchenko, T. P.
    Ponomarenko, S., V
    PATHOLOGIA, 2020, (03): : 390 - 401
  • [26] Epstein-Barr Virus in Multiple Sclerosis
    Toscano, M. P.
    Cohen, C.
    Hunter, S. B.
    LABORATORY INVESTIGATION, 2009, 89 : 335A - 335A
  • [27] Epstein-barr virus in multiple sclerosis
    Bagert, Bridget A.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2009, 9 (05) : 405 - 410
  • [28] Epstein-Barr virus and multiple sclerosis
    Lovett-Racke, Amy E.
    Racke, Michael K.
    ARCHIVES OF NEUROLOGY, 2006, 63 (06) : 810 - 811
  • [29] Epstein-Barr virus and multiple sclerosis
    Lucas, R. M.
    Hughes, A. M.
    Lay, M-L J.
    Ponsonby, A-L
    Dwyer, D. E.
    Taylor, B. V.
    Pender, M. P.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (10): : 1142 - 1148
  • [30] Epstein-Barr virus and multiple sclerosis
    Salvetti, Marco
    Giovannoni, Gavin
    Aloisi, Francesca
    CURRENT OPINION IN NEUROLOGY, 2009, 22 (03) : 201 - 206