Clinical outcomes in patients with early non-small-cell lung cancer treated surgically in Bogota (Colombia)

Introduction: In Colombia, information is limited on the survival of patients with lung cancer treated in the early stages. Thus, this study aimed to analyze the clinical outcomes and factors associated with the prognosis of patients with non-small-cell lung cancer (NSCLC) treated surgically in three institutions in Bogota.Methods: Analytical, observational, retrospective, and multicenter study.Results: The study included 101 patients with a median age of 69 years (IQR 63-75); 56 were women (55.4%). Of the patients, 8 (7.9%) had pathological stage 0, 83 (82.2%) were in stage I and 10 (9.9%) in stage II. The 3-year disease-free survival (DFS) of patients with stages 0, I, and II was 100%, 97%, and 58%, respectively. The overall survival (OS) of all included patients at 3 years was 94%. The OS of patients with and without relapse was 78% and 96%. A statistically significant association was found between relapse and stage II (P<0.001), relapse and T3 (P=0.048), relapse and N1 (P<0.001), and relapse and visceral pleura invasion (P=0.002). The only association found with death was relapse (P=0.002).Conclusions: The pathological stage and some special TNM characteristics, such as T3 tumor, the presence of N1 disease, and visceral pleura invasion, were determining factors in DFS. In contrast, the only factor associated with worse OS was relapse.