Multicomponent Reactions for Expeditious Construction of β-Indole Carboxamide Amino Amides

被引：2
|
作者：
Yu, Mengyao [1 ]
Zeng, Linwei [1 ]
Xu, Gang [2 ]
Cui, Sunliang [1 ]
机构：
[1] Zhejiang Univ, Inst Drug Discovery & Design, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310058, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 16期
基金：
中国国家自然科学基金;
关键词：
EFFICIENT SYNTHESIS; PRODUCTS; FUNCTIONALIZATION; INDOLES;
D O I：
10.1021/acs.joc.3c01426
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponentreaction of N-indole carboxylicacids, aldehydes, amines, and C2 building blocks can be transformedto structurally diverse & beta;-indole carboxamide amino amides. Inthis multicomponent reaction, the ynamides and triazenyl alkynes actas the C2 building block, and this protocol features readily availablestarting materials, high atom economy, and mild reaction conditions.Besides, the acyl triazene group in the product can be easily transformedto differential groups to expand the structural diversity.
引用
收藏
页码：12150 / 12161
页数：12
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