Plan quality association between dummy run and individual case review in a prospective multi-institutional clinical trial of postoperative cervical cancer patients treated with intensity-modulated radiotherapy: Japan clinical Oncology Group study (JCOG1402)

被引：2

作者：

Okamoto, Hiroyuki ^{[1
]}

Murakami, Naoya ^{[2
,3
]}

Isohashi, Fumiaki ^{[4
]}

Kasamatsu, Takahiro ^{[5
]}

Hasumi, Yoko ^{[6
]}

Kobayashi, Hiroaki ^{[7
]}

Ishikawa, Masayori ^{[8
]}

Nakamura, Mitsuhiro ^{[9
]}

Nishio, Teiji ^{[10
]}

Igaki, Hiroshi ^{[2
]}

Ishikura, Satoshi ^{[11
]}

Yaegashi, Nobuo ^{[12
]}

Mizowaki, Takashi ^{[13
]}

Nishimura, Yasumasa ^{[14
]}

Toita, Takafumi ^{[15
]}

机构：

[1] Natl Canc Ctr, Radiat Safety & Qual Assurance Div, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Dept Radiat Oncol, 5-1-1 Tsukiji,Chuo Ku, Tokyo 1040045, Japan

[3] Juntendo Univ, Dept Radiat Oncol, Tokyo 1130033, Japan

[4] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, Osaka 5650871, Japan

[5] Tokyo Metropolitan Bokutoh Hosp, Dept Obstet & Gynecol, Tokyo 1308575, Japan

[6] Mitsui Mem Hosp, Dept Obstet & Gynaecol, Tokyo 1018643, Japan

[7] Kagoshima Univ, Fac Med, Dept Obstet & Gynecol, Kagoshima 8908544, Japan

[8] Hokkaido Univ, Fac Hlth Sci, Hokkaido 0600812, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Adv Med Phys, Kyoto 6068507, Japan

[10] Osaka Univ, Grad Sch Med, Div Hlth Sci, Med Phys Lab, Osaka 5650871, Japan

[11] Tokyo Bay Makuhari Clin Adv Imaging Canc Screening, Div Radiat Oncol, Chiba 2610024, Japan

[12] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Miyagi 9808574, Japan

[13] Kyoto Univ, Grad Sch Med, Dept Radiat Oncol & Image Appl Therapy, Kyoto 6068507, Japan

[14] Kindai Univ, Fac Med, Dept Radiat Oncol, Osaka 5898511, Japan

[15] Okinawa Chubu Hosp, Radiat Therapy Ctr, Okinawa 9042293, Japan

来源：

RADIOTHERAPY AND ONCOLOGY | 2023年 / 183卷

关键词：

Cervical cancer; Quality assurance; Individual case review; Dummy run; TARGET VOLUME; VAGINAL CUFF; ASSURANCE; VMAT;

D O I：

10.1016/j.radonc.2023.109630

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: The Japan Clinical Oncology Group (JCOG) 1402 conducted a multicenter clinical trial of postoperative intensity-modulated radiotherapy (IMRT) for high-risk uterine cervical cancer patients. We assess effectiveness of the quality assurance (QA) program in central review through dummy runs (DRs) performed before patient enrollment and post-treatment individual case review (ICR), and clarify the pitfalls in treatment planning. Material and methods: The ICRs were conducted using the same QA program as the DR for 214 plans. The deviations were compared with those demonstrated in the DRs, and the pitfalls were clarified. Fifteen face-to-face meetings were held with physicians at participating institutions to provide feedback.Results: Two-hundred and eighty-eight deviations and nine violations were detected in the 214 plans. The patterns of the deviations observed in the ICRs were similar to that in the DR. Frequent deviations were observed in clinical target volume (CTV) delineations, 50% in the DRs and 37% in the ICRs, respec-tively. In the ICRs, approximately 1.4 deviations/violations were observed per plan, which was lower than DR. Nine violations included inaccurate CTV delineation and improper PTV (planning target volume) mar-gin, which had risks in loco-regional failures by inadequate dose coverage.Conclusions: Our developed QA program commonly used in DR and ICR clarified the pitfalls in treatment plans. Although the frequent deviations in CTV delineations were observed in the ICR, the deviations decreased compared to that in the DR. More specified face-to-face meetings with participating institu-tions will be necessary to maintain the quality of IMRT in the clinical protocol.(c) 2023 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 183 (2023) 109630

引用

页数：7

共 16 条

[11] Quality Assurance in the Prospective Multi-institutional Trial on Definitive Radiotherapy Using High-dose-rate Intracavitary Brachytherapy for Uterine Cervical Cancer: The Individual Case Review
Toita, Takafumi
Oguchi, Masahiko
Ohno, Tatsuya
Kato, Shingo
Niibe, Yuzuru
Kodaira, Takeshi
Kazumoto, Tomoko
Kataoka, Masaaki
Shikama, Naoto
Kenjo, Masahiro
Teshima, Teruki
Kagami, Yoshikazu
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2009, 39 (12) : 813 - 819
[12] QUALITY ASSURANCE FOR A PROSPECTIVE MULTI-INSTITUTIONAL TRIAL OF DEFINITIVE RADIOTHERAPY USING HIGH-DOSE-RATE INTRACAVITARY BRACHYTHERAPY FOR UTERINE CERVICAL CANCER: THE INDIVIDUAL CASE REVIEW
Toita, T.
Oguchi, M.
Ohno, T.
Kato, S.
Niibe, Y.
Kodaira, T.
Kazumoto, T.
Kataoka, M.
Shikama, N.
Kenjo, M.
Teshima, T.
Hayakawa, K.
Kagami, Y.
RADIOTHERAPY AND ONCOLOGY, 2008, 88 : S245 - S246
[13] A multi-institutional randomized phase III trial comparing postoperative radiotherapy to observation after adjuvant chemotherapy in patients with pathological N2 Stage III non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG1916 (J-PORT study)
Shimoyama, Ryo
Nakagawa, Kazuo
Ishikura, Satoshi
Wakabayashi, Masashi
Sasaki, Tomonari
Yoshioka, Hiroshige
Hashimoto, Tadayoshi
Kataoka, Tomoko
Fukuda, Haruhiko
Watanabe, Shun-Ichi
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 51 (06) : 999 - 1003
[14] A multi-institutional randomized phase III trial comparing anatomical segmentectomy and wedge resection for clinical stage IA non-small cell lung cancer in high-risk operable patients: Japan Clinical Oncology Group Study JCOG1909 (ANSWER study)
Shimoyama, Ryo
Tsutani, Yasuhiro
Wakabayashi, Masashi
Katayama, Hiroshi
Fukuda, Haruhiko
Suzuki, Kenji
Watanabe, Shun-ichi
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2020, 50 (10) : 1209 - 1213
[15] Results of a multi-institutional, randomized, non-inferiority, phase III trial of accelerated fractionation versus standard fractionation in radiation therapy for T1-2N0M0 glottic cancer: Japan Clinical Oncology Group Study JCOG0701)
Kodaira, T.
Kagami, Y.
Shibata, T.
Shikama, N.
Nishimura, Y.
Ishikura, S.
Nakamura, K.
Saito, Y.
Matsumoto, Y.
Teshima, T.
Ito, Y.
Akimoto, T.
Nakata, K.
Toshiyasu, T.
Nakagawa, K.
Nagata, Y.
Nishimura, T.
Uno, T.
Kataoka, M.
Yorozu, A.
Hiraoka, M.
ANNALS OF ONCOLOGY, 2018, 29 (04) : 992 - 997
[16] A multi-institutional randomized phase III study comparing weekly carboplatin plus nab-paclitaxel and daily low-dose carboplatin as regimens for concurrent chemoradiotherapy in elderly patients with unresectable locally advanced non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG1914
Shimoyama, Ryo
Omori, Shota
Nomura, Shogo
Kenmotsu, Hirotsugu
Takahashi, Toshiaki
Harada, Hideyuki
Ishikura, Satoshi
Mizutani, Tomonori
Ando, Masahiko
Kataoka, Tomoko
Fukuda, Haruhiko
Ohe, Yuichiro
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 51 (05) : 836 - 841

← 1 2 →