Plan quality association between dummy run and individual case review in a prospective multi-institutional clinical trial of postoperative cervical cancer patients treated with intensity-modulated radiotherapy: Japan clinical Oncology Group study (JCOG1402)

被引：2

作者：

Okamoto, Hiroyuki ^{[1
]}

Murakami, Naoya ^{[2
,3
]}

Isohashi, Fumiaki ^{[4
]}

Kasamatsu, Takahiro ^{[5
]}

Hasumi, Yoko ^{[6
]}

Kobayashi, Hiroaki ^{[7
]}

Ishikawa, Masayori ^{[8
]}

Nakamura, Mitsuhiro ^{[9
]}

Nishio, Teiji ^{[10
]}

Igaki, Hiroshi ^{[2
]}

Ishikura, Satoshi ^{[11
]}

Yaegashi, Nobuo ^{[12
]}

Mizowaki, Takashi ^{[13
]}

Nishimura, Yasumasa ^{[14
]}

Toita, Takafumi ^{[15
]}

机构：

[1] Natl Canc Ctr, Radiat Safety & Qual Assurance Div, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Dept Radiat Oncol, 5-1-1 Tsukiji,Chuo Ku, Tokyo 1040045, Japan

[3] Juntendo Univ, Dept Radiat Oncol, Tokyo 1130033, Japan

[4] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, Osaka 5650871, Japan

[5] Tokyo Metropolitan Bokutoh Hosp, Dept Obstet & Gynecol, Tokyo 1308575, Japan

[6] Mitsui Mem Hosp, Dept Obstet & Gynaecol, Tokyo 1018643, Japan

[7] Kagoshima Univ, Fac Med, Dept Obstet & Gynecol, Kagoshima 8908544, Japan

[8] Hokkaido Univ, Fac Hlth Sci, Hokkaido 0600812, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Adv Med Phys, Kyoto 6068507, Japan

[10] Osaka Univ, Grad Sch Med, Div Hlth Sci, Med Phys Lab, Osaka 5650871, Japan

[11] Tokyo Bay Makuhari Clin Adv Imaging Canc Screening, Div Radiat Oncol, Chiba 2610024, Japan

[12] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Miyagi 9808574, Japan

[13] Kyoto Univ, Grad Sch Med, Dept Radiat Oncol & Image Appl Therapy, Kyoto 6068507, Japan

[14] Kindai Univ, Fac Med, Dept Radiat Oncol, Osaka 5898511, Japan

[15] Okinawa Chubu Hosp, Radiat Therapy Ctr, Okinawa 9042293, Japan

来源：

RADIOTHERAPY AND ONCOLOGY | 2023年 / 183卷

关键词：

Cervical cancer; Quality assurance; Individual case review; Dummy run; TARGET VOLUME; VAGINAL CUFF; ASSURANCE; VMAT;

D O I：

10.1016/j.radonc.2023.109630

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: The Japan Clinical Oncology Group (JCOG) 1402 conducted a multicenter clinical trial of postoperative intensity-modulated radiotherapy (IMRT) for high-risk uterine cervical cancer patients. We assess effectiveness of the quality assurance (QA) program in central review through dummy runs (DRs) performed before patient enrollment and post-treatment individual case review (ICR), and clarify the pitfalls in treatment planning. Material and methods: The ICRs were conducted using the same QA program as the DR for 214 plans. The deviations were compared with those demonstrated in the DRs, and the pitfalls were clarified. Fifteen face-to-face meetings were held with physicians at participating institutions to provide feedback.Results: Two-hundred and eighty-eight deviations and nine violations were detected in the 214 plans. The patterns of the deviations observed in the ICRs were similar to that in the DR. Frequent deviations were observed in clinical target volume (CTV) delineations, 50% in the DRs and 37% in the ICRs, respec-tively. In the ICRs, approximately 1.4 deviations/violations were observed per plan, which was lower than DR. Nine violations included inaccurate CTV delineation and improper PTV (planning target volume) mar-gin, which had risks in loco-regional failures by inadequate dose coverage.Conclusions: Our developed QA program commonly used in DR and ICR clarified the pitfalls in treatment plans. Although the frequent deviations in CTV delineations were observed in the ICR, the deviations decreased compared to that in the DR. More specified face-to-face meetings with participating institu-tions will be necessary to maintain the quality of IMRT in the clinical protocol.(c) 2023 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 183 (2023) 109630

引用

页数：7

共 16 条

[1] Dummy-run for standardizing plan quality of intensity-modulated radiotherapy for postoperative uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402)
Okamoto, Hiroyuki
Murakami, Naoya
Isohashi, Fumiaki
Kasamatsu, Takahiro
Hasumi, Yoko
Iijima, Kotaro
Nishioka, Shie
Nakamura, Satoshi
Nakamura, Mitsuhiro
Nishio, Teiji
Igaki, Hiroshi
Nakayama, Yuko
Itami, Jun
Ishikura, Satoshi
Nishimura, Yasumasa
Toita, Takafumi
RADIATION ONCOLOGY, 2019, 14 (1)
[2] Dummy-run for standardizing plan quality of intensity-modulated radiotherapy for postoperative uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402)
Hiroyuki Okamoto
Naoya Murakami
Fumiaki Isohashi
Takahiro Kasamatsu
Yoko Hasumi
Kotaro Iijima
Shie Nishioka
Satoshi Nakamura
Mitsuhiro Nakamura
Teiji Nishio
Hiroshi Igaki
Yuko Nakayama
Jun Itami
Satoshi Ishikura
Yasumasa Nishimura
Takafumi Toita
Radiation Oncology, 14
[3] Dummy run study for outlining and plan quality of intensity-modulated radiotherapy in elderly patients with newly diagnosed glioblastoma: The Japan clinical oncology group study JCOG1910 (AgedGlio-PIII)
Ono, Tomohiro
Uto, Megumi
Mineharu, Yohei
Arakawa, Yoshiki
Nakamura, Mitsuhiro
Nishio, Teiji
Igaki, Hiroshi
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Ishikura, Satoshi
Narita, Yoshitaka
Mizowaki, Takashi
Brain Tumor Study Grp
Radiat Therapy Study Grp
Japan Clin Oncol Grp
RADIATION ONCOLOGY, 2025, 20 (01)
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Murakami, Naoya
Isohashi, Fumiaki
Hasumi, Yoko
Kasamatsu, Takahiro
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Nakamura, Kenichi
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Ishikura, Satoshi
Nishimura, Yasumasa
Yaegashi, Nobuo
Toita, Takafumi
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 49 (09) : 881 - 885
[5] Radiotherapy quality assurance review for a multi-center randomized trial of locally advanced esophageal cancer: the Japan Clinical Oncology Group (JCOG) trial 0303
Sanuki, Naoko
Ishikura, Satoshi
Shinoda, Masayuki
Ito, Yoshinori
Hayakawa, Kazushige
Ando, Nobutoshi
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2012, 17 (02) : 105 - 111
[6] Radiotherapy quality assurance review for a multi-center randomized trial of locally advanced esophageal cancer: the Japan Clinical Oncology Group (JCOG) trial 0303
Naoko Sanuki
Satoshi Ishikura
Masayuki Shinoda
Yoshinori Ito
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International Journal of Clinical Oncology, 2012, 17 : 105 - 111
[7] Radiotherapy quality assurance review in a multi-center randomized trial of limited-disease small cell lung cancer: the Japan Clinical Oncology Group (JCOG) trial 0202
Naoko Sanuki-Fujimoto
Satoshi Ishikura
Kazushige Hayakawa
Kaoru Kubota
Yutaka Nishiwaki
Tomohide Tamura
Radiation Oncology, 4
[8] Radiotherapy quality assurance review in the multi-center randomized trial for limited-disease small cell lung cancer: The Japan Clinical Oncology Group (JCOG) trial 0202
Sanuki-Fujimoto, N.
Ishikura, S.
Kubota, K.
Nishiwaki, H.
Tamura, T.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 72 (01): : S449 - S449
[9] Radiotherapy quality assurance review in a multi-center randomized trial of limited-disease small cell lung cancer: the Japan Clinical Oncology Group (JCOG) trial 0202
Sanuki-Fujimoto, Naoko
Ishikura, Satoshi
Hayakawa, Kazushige
Kubota, Kaoru
Nishiwaki, Yutaka
Tamura, Tomohide
RADIATION ONCOLOGY, 2009, 4
[10] Insufficiency Fractures after Pelvic Radiotherapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)
Tokumaru, S.
Toita, T.
Kato, S.
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Kazumoto, T.
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Kataoka, M.
Ohno, T.
Kenjo, M.
Oguchi, M.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (03): : S410 - S411

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