Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

被引:2
|
作者
Mcgettrick, Padraig [1 ,2 ]
Tinago, Willard [1 ]
O'Brien, Julie [3 ]
Miles, Sarah [1 ]
Lawler, Leo [4 ]
Garcia-Leon, Alejandro [1 ]
Mahon, Niall [5 ]
Lambert, John [2 ]
Sheehan, Gerard [2 ]
Landay, Alan [6 ]
Sabin, Caroline A. [7 ]
Cotter, Aoife G. [2 ]
Mallon, Patrick W. G. [1 ,8 ]
机构
[1] Univ Coll Dublin, Ctr Expt Pathogen Host Res, Dublin, Ireland
[2] Mater Misericordiae Univ Hosp, Dept Infect Dis, Dublin, Ireland
[3] Univ Hosp Limerick, Dept Radiol, Limerick, Ireland
[4] Mater Misericordiae Univ Hosp, Dept Radiol, Dublin, Ireland
[5] Mater Misericordiae Univ Hosp, Dept Cardiol, Dublin, Ireland
[6] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL USA
[7] UCL, Inst Global Hlth, London, England
[8] St Vincents Univ Hosp, Dept Infect Dis, Dublin, Ireland
来源
JOURNAL OF INFECTIOUS DISEASES | 2024年 / 230卷 / 03期
关键词
CVD; inflammation; subclinical CAD; Inflammatory phenotypes; HIV;
D O I
10.1093/infdis/jiae007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.
引用
收藏
页码:E616 / E621
页数:6
相关论文
共 50 条
  • [11] Cardiovascular disease in human immunodeficiency virus
    Cheruvu, S.
    Holloway, C. J.
    INTERNAL MEDICINE JOURNAL, 2014, 44 (04) : 315 - 324
  • [12] Clinical Burden of Herpes Simplex Virus Disease in People With Human Immunodeficiency Virus
    Keating, Tamarind M.
    Kurth, Ann E.
    Wald, Anna
    Kahle, Erin M.
    Barash, Elizabeth A.
    Buskin, Susan E.
    SEXUALLY TRANSMITTED DISEASES, 2012, 39 (05) : 372 - 376
  • [13] Cardiovascular Disease Risk Factor Control in People With and Without Human Immunodeficiency Virus
    Silverberg, Michael J.
    Levine, Tory M.
    Lea, Alexandra N.
    Williams, Andrew E.
    Alexeeff, Stacey E.
    Bryant, Kendall
    Cavassini, Matthias
    Flamm, Jason A.
    Hare, C. Bradley
    Ingle, Suzanne M.
    Justice, Amy C.
    Lam, Jennifer O.
    Sterling, Stacy A.
    Horberg, Michael A.
    Satre, Derek D.
    CLINICAL INFECTIOUS DISEASES, 2024, 78 (05) : 1264 - 1271
  • [14] Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy
    Turcotte, Isabelle
    El-Far, Mohamed
    Sadouni, Manel
    Chartrand-Lefebvre, Carl
    Filali-Mouhim, Ali
    Fromentin, Remi
    Chamberland, Annie
    Jenabian, Mohammad-Ali
    Baril, Jean-Guy
    Trottier, Benoit
    Thomas, Rejean
    Tremblay, Cecile L.
    Durand, Madeleine
    Chomont, Nicolas
    Canadian HIV Aging Cohort Study
    CLINICAL INFECTIOUS DISEASES, 2023, 76 (07) : 1318 - 1321
  • [15] Influence of immune activation and inflammatory response on cardiovascular risk associated with the human immunodeficiency virus
    Beltran, Luis M.
    Rubio-Navarro, Alfonso
    Manuel Amaro-Villalobos, Juan
    Egido, Jess
    Garcia-Puig, Juan
    Antonio Moreno, Juan
    VASCULAR HEALTH AND RISK MANAGEMENT, 2015, 11 : 35 - 48
  • [16] Is human immunodeficiency virus infection an inflammatory disease?
    Gutierrez, Felix
    Masia, Mar
    MEDICINA CLINICA, 2012, 138 (04): : 157 - 159
  • [17] Clonal Hematopoiesis Is Associated with Risk of Cardiovascular Disease in Individuals with Human Immunodeficiency Virus
    Wiley, Brian
    Erlandson, Kristin
    Tassiopoulos, Katherine
    Song, Yizhe
    Presti, Rachel
    Bolton, Kelly L.
    Challen, Grant A.
    BLOOD, 2021, 138
  • [18] Defining the Link between Pulmonary and Cardiovascular Disease for People Living with Human Immunodeficiency Virus
    Raju, Sarath
    McCormack, Meredith C.
    ANNALS OF THE AMERICAN THORACIC SOCIETY, 2019, 16 (06) : 672 - 673
  • [19] Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus
    Lyndaker, Anna
    Lau, Chuen-Yen
    Shah, Swati
    Wakim, Paul
    Kelly, Erin
    Horne, Elizabeth
    Mcmahan, Cynthia
    Spiegel, Alicia
    Gollomp, Elyse
    Chien, Alice
    Mitchell, Amelia
    Monroe, Cynthia
    Kim, Alan
    Nair, Govind
    Snow, Joseph
    Smith, Bryan
    Nath, Avindra
    Hammoud, Dima A.
    OPEN FORUM INFECTIOUS DISEASES, 2024, 11 (10):
  • [20] Distinct Gut Microbiota Signatures Associated With Progression of Atherosclerosis in People Living With Human Immunodeficiency Virus
    Masia, Mar
    Garcia, Jose A.
    Garcia-Abellan, Javier
    Padilla, Sergio
    Fernandez-Gonzalez, Marta
    Agullo, Vanesa
    Gosalbes, Maria Jose
    Ruiz-Perez, Sonia
    Mascarell, Paula
    Botella, Angela
    Gutierrez, Felix
    JOURNAL OF INFECTIOUS DISEASES, 2024,