How to Build a Fire: The Genetics of Autoinflammatory Diseases
被引:7
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作者:
Zhang, Jiahui
论文数: 0引用数: 0
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机构:
Zhejiang Univ, Inst Life Sci, Hangzhou, Peoples R ChinaZhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Zhang, Jiahui
[1
]
Lee, Pui Y.
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机构:
Harvard Med Sch, Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USAZhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Lee, Pui Y.
[2
]
Aksentijevich, Ivona
论文数: 0引用数: 0
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机构:
Zhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Natl Human Genome Res Inst, Natl Inst Hlth, Inflammat Dis Sect, Bethesda, MD 20892 USAZhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Aksentijevich, Ivona
[1
,3
]
Zhou, Qing
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机构:
Zhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Zhejiang Univ Med Ctr, Liangzhu Lab, Hangzhou, Peoples R ChinaZhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
Zhou, Qing
[1
,4
]
机构:
[1] Zhejiang Univ, Inst Life Sci, Hangzhou, Peoples R China
[2] Harvard Med Sch, Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA
[3] Natl Human Genome Res Inst, Natl Inst Hlth, Inflammat Dis Sect, Bethesda, MD 20892 USA
[4] Zhejiang Univ Med Ctr, Liangzhu Lab, Hangzhou, Peoples R China
Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders caused by excess activation of the innate immune system in an antigen-independent manner. Starting with the discovery of the causal gene for familial Mediterranean fever, more than 50 monogenic SAIDs have been described. These discoveries, paired with advances in immunology and genomics, have allowed our understanding of these diseases to improve drastically in the last decade. The genetic causes of SAIDs are complex and include both germline and somatic pathogenic variants that affect various inflammatory signaling pathways. We provide an overview of the acquired SAIDs from a genetic perspective and summarize the clinical phenotypes and mechanism(s) of inflammation, aiming to provide a comprehensive understanding of the pathogenesis of autoinflammatory diseases.
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran
Univ Tehran Med Sci, Dept Pediat, Tehran, Iran
Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, IranUniv Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran
Ashari, Kosar Asna
Hausmann, Jonathan S.
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机构:
Harvard Med Sch, Boston Childrens Hosp, Dept Med, Div Immunol,Rheumatol Program, Boston, MA USA
Massachusetts Gen Hosp, Dept Med, Div Rheumatol Dermatol Allergy & Immunol, Boston, MA USAUniv Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran
Hausmann, Jonathan S.
Dedeoglu, Fatma
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h-index: 0
机构:
Harvard Med Sch, Boston Childrens Hosp, Dept Med, Div Immunol,Rheumatol Program, Boston, MA USA
Boston Childrens Hosp, Boston, MA 02115 USAUniv Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran
机构:
Hosp Ninos Dr Ricardo Gutierrez, Div Rheumatol, Buenos Aires, DF, ArgentinaHosp Ninos Dr Ricardo Gutierrez, Div Rheumatol, Buenos Aires, DF, Argentina
Meiorin, Silvia M.
Espada, Graciela
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Ninos Dr Ricardo Gutierrez, Div Rheumatol, Buenos Aires, DF, ArgentinaHosp Ninos Dr Ricardo Gutierrez, Div Rheumatol, Buenos Aires, DF, Argentina
Espada, Graciela
Rose, Carlos
论文数: 0引用数: 0
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机构:
Nemours Alfred I duPont Hosp Children, Delaware, OH USAHosp Ninos Dr Ricardo Gutierrez, Div Rheumatol, Buenos Aires, DF, Argentina
Rose, Carlos
ARCHIVOS ARGENTINOS DE PEDIATRIA,
2013,
111
(03):
: 237
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243
机构:
Hop Bicetre, Serv Rhumatol Pediat, 78,Rue Gen Leclerc, F-94270 Le Kremlin Bicetre, France
Univ Paris Saclay, CEREMAIA, Paris, FranceHop Bicetre, Serv Rhumatol Pediat, 78,Rue Gen Leclerc, F-94270 Le Kremlin Bicetre, France