Role of Semaphorin 3A in Kidney Development and Diseases

被引：2
|
作者：
Sang, Yizhen [1 ,2 ]
Tsuji, Kenji [1 ]
Nakanoh, Hiroyuki [1 ]
Fukushima, Kazuhiko [1 ,3 ,4 ]
Kitamura, Shinji [1 ,5 ]
Wada, Jun [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Nephrol Rheumatol Endocrinol & Metab, 2-5-1 Shikata Cho, Okayama 7008558, Japan
[2] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Rheumatol & Immunol, Shanghai 200072, Peoples R China
[3] Massachusetts Gen Hosp, Ctr Syst Biol, Dept Med, Program Membrane Biol,Div Nephrol, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02114 USA
[5] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nursing Sci, Okayama 7191197, Japan
来源：
DIAGNOSTICS | 2023年 / 13卷 / 19期
关键词：
semaphorin; 3A; neuropilin-1; podocyte; diabetic nephropathy; acute kidney injury; chronic kidney injury; lupus nephritis; fibrosis; apoptosis; inflammation; PODOCYTE SHAPE; GUIDANCE CUE; INJURY; INFLAMMATION; BIOMARKERS; EXPRESSION; PREDICTS; PROMOTES; PROTEIN; PLEXINS;
D O I：
10.3390/diagnostics13193038
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases.
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页数：16
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