Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?

被引：1

作者：

Lapadula, L. ^{[1
]}

Piombino, M. ^{[2
]}

Bianculli, A. ^{[1
]}

Caivano, R. ^{[1
]}

Capobianco, A. ^{[3
]}

Cacciatore, A. ^{[1
]}

Cozzolino, M. ^{[1
]}

Oliviero, C. ^{[1
]}

D'andrea, B. ^{[1
]}

Mileo, A. ^{[4
]}

Leone, A. ^{[5
,6
]}

Carbone, F. ^{[5
,7
]}

Fochi, N. P. ^{[7
]}

Landriscina, M. ^{[8
]}

Colamaria, A. ^{[9
]}

Giordano, G. ^{[8
]}

机构：

[1] IRCCS CROB, Radiat Oncol Dept, Rionero In Vulture, Italy

[2] Policlin Bari, AUOC, Radiat Oncol Dept, Bari, Italy

[3] IRCCS Referral Canc Ctr Basilicata CROB, Hlth Directorate Dept, Multidisciplinary Oncol, Rionero In Vulture, Italy

[4] IRCCS Referral Canc Ctr Basilicata CROB, Oncol Unit, Rionero In Vulture, Italy

[5] Stadt Klinikum Karlsruhe, Dept Neurosurg, Karlsruhe, Germany

[6] Charite Univ Med Berlin, Fac Human Med, Berlin, Germany

[7] Univ Foggia, Riuniti Hosp, Div Neurosurg, I-71121 Foggia, FG, Italy

[8] Univ Foggia, Dept Med & Surg Sci, Unit Med Oncol, I-71122 Foggia, Italy

[9] Policlin Riuniti, Div Neurosurg, Foggia, Italy

来源：

CANCER RADIOTHERAPIE | 2023年 / 27卷 / 08期

关键词：

WBRT; SRS; KPS; Brain metastasis; Radiotherapy; Reirradiation; REIRRADIATION; TOXICITY; TUMORS; RTOG;

D O I：

10.1016/j.canrad.2023.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Whole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been administered to highly selected patients to obtain disease control and delay progression. Clinical outcomes and neurological toxicity were also evaluated. (c) 2023 Societe franc, aise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：725 / 730

页数：6

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