A flexible system for tissue-specific gene expression in mice using adeno-associated virus

被引：0

作者：

Zengel, James ^{[1
]}

Carette, Jan E. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Stanford, CA 94305 USA

来源：

NATURE METHODS | 2023年 / 20卷 / 07期

关键词：

D O I：

10.1038/s41592-023-01897-w

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell type-specific transgene expression in mice has broad utility in biomedical research. We developed a versatile system for in vivo transgene delivery using adeno-associated virus (AAV). Efficient and tissue-specific transgene expression is achieved by regulating the expression of the gene encoding the AAV receptor, thereby precisely targeting AAV to the cell type of interest.

引用

页码：997 / 998

页数：2

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