New kids on the block: FOS and FOSB gene

被引：3
|
作者：
Cordier, Fleur [1 ]
Creytens, David [1 ,2 ]
机构：
[1] Ghent Univ Hosp, Dept Pathol, Ghent, Belgium
[2] Ghent Univ Hosp, Pathol, Ghent, Belgium
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2023年 / 76卷 / 11期
关键词：
soft tissue neoplasms; bone and bones; molecular biology; immunohistochemistry; SPINDLE-CELL HEMANGIOMA; C-FOS; EPITHELIOID HEMANGIOMA; PROLIFERATIVE MYOSITIS; OSTEOID OSTEOMA; OSTEOBLASTOMA; EXPRESSION; TUMOR; BONE; FAMILY;
D O I：
10.1136/jcp-2023-208931
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
FOS and FOSB proto-oncogens are involved in a wide variety of tumourigenic processes. FOS and FOSB gene rearrangements are observed in epithelioid haemangioma, pseudomyogenic haemangioendothelioma, osteoid osteoma/osteoblastoma/cementoblastoma and proliferative myositis/fasciitis. In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS/FOSB immunohistochemistry as a diagnostic tool for these lesions.
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页码：721 / 726
页数：6
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