Sarcomatoid malignant pleural mesothelioma associated with anti-Ma2-related paraneoplastic neurological syndrome: A case report

被引：0

作者：

Tada, Akio ^{[1
]}

Kuribayashi, Kozo ^{[1
]}

Kitajima, Kazuhiro ^{[2
]}

Nakamura, Akifumi ^{[3
]}

Yuki, Michiko ^{[4
]}

Kanemura, Shingo ^{[1
]}

Shibata, Eisuke ^{[1
]}

Negi, Yoshiki ^{[1
]}

Ishigaki, Hirotoshi ^{[5
]}

Nakajima, Yasuhiro ^{[1
]}

Takahashi, Ryo ^{[1
]}

Yokoi, Takashi ^{[1
]}

Minami, Toshiyuki ^{[1
]}

Kijima, Takashi ^{[1
]}

机构：

[1] Hyogo Med Univ, Dept Resp Med & Hematol, Sch Med, 1-1 Mukogawa cho, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Med Univ, Dept Radiol, Sch Med, Nishinomiya, Hyogo, Japan

[3] Hyogo Med Univ, Div Thorac Surg, Sch Med, Nishinomiya, Hyogo, Japan

[4] Hyogo Med Univ, Dept Mol Pathol, Sch Med, Nishinomiya, Hyogo, Japan

[5] Asahi Univ Hosp, Dept Respirol, Gifu, Japan

来源：

CURRENT PROBLEMS IN CANCER: CASE REPORTS | 2023年 / 11卷

关键词：

Anti-Ma2; antibodies; Cerebellar degeneration; Immunoglobulin therapy; Paraneoplastic syndrome; Sarcomatoid mesothelioma;

D O I：

10.1016/j.cpccr.2023.100244

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paraneoplastic neurological syndrome (PNS) is rarely associated with malignant pleural mesothelioma (MPM). We report the first case of sarcomatoid mesothelioma in a 63-year-old female diagnosed with cerebellar degeneration in January 2018. Systemic examination showed right pleura thickening. The pleural biopsy of the mass revealed a sarcomatoid MPM cT3N0M0. In February 2018, anti-Ma2 antibody positivity indicated PNS complicated with MPM. First, cisplatin (75 mg/m2) + pemetrexed (500 mg/m2) chemotherapy was given. For PNS, steroid pulse therapy and high-dose immunoglobulin therapy were administered. MPM may cause anti-Ma2 antibody-related PNS. Early diagnosis and starting anticancer treatment and immunotherapy are critical.

引用

页数：4

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