Modulation of cytokine release from peripheral blood mononuclear cells from multiple sclerosis patients by coenzyme A and soraphen A

被引：1

作者：

Blask, Carolin ^{[1
]}

Schulze, Juliane ^{[1
]}

Ruempel, Sarah ^{[1
]}

Suess, Marie ^{[1
]}

Grothe, Matthias ^{[1
]}

Gross, Stefan ^{[3
]}

Dressel, Alexander ^{[2
]}

Mueller, Rolf ^{[4
,5
]}

Ruhnau, Johanna ^{[1
]}

Vogelgesang, Antje ^{[1
]}

机构：

[1] Univ Med Greifswald, Dept Neurol, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany

[2] Carl Thiem Klinikum, Dept Neurol, Cottbus, Germany

[3] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany

[4] Saarland Univ, Helmholtz Inst Pharmaceut Res Saarland HIPS, Helmholtz Ctr Infect Res HZI, Dept Microbial Nat Prod, Campus E8 1, D-66123 Saarbrucken, Germany

[5] Saarland Univ, Dept Pharm, Campus E8 1, D-66123 Saarbrucken, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 381卷

关键词：

Multiple sclerosis; Cytokines; Fatty acid metabolism; Soraphen A; Coenzyme A; Acetyl-CoA-carboxylase; Th17; cells; Treg; REGULATORY T-CELLS; FATTY-ACID SYNTHESIS; TH17; CELLS; GENE-THERAPY; INHIBITION; PATHOGENESIS; CARBOXYLASE; IL-17; CNS;

D O I：

10.1016/j.jneuroim.2023.578135

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By applying the acetyl-CoA-carboxylase inhibitors soraphen A (SorA) and coenzyme A (CoA) ex vivo, we aimed to reduce proinflammatory cytokine release by PBMCs and increase anti-inflammatory cytokine levels, thereby demonstrating a possible application of those pathways in future multiple sclerosis (MS) therapy. In a prospective exploratory monocentric study, we analysed cytokine production by PBMCs treated with SorA (10 or 50 nM) and CoA (600 & mu;M). Thirty-one MS patients were compared to 18 healthy age-matched controls. We demonstrated the immunomodulatory potential of SorA and CoA in targeting the immune function of MS patients, with an overall reduction of cytokines except of IL-2, IL-6 and IL-10.

引用

页数：9

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