Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

被引:2
|
作者
Groenen, Patricia J. T. A. [1 ,2 ]
van den Brand, Michiel [1 ,3 ]
Kroeze, Leonie I. [1 ,2 ]
Amir, Avital L. [1 ]
Hebeda, Konnie M. [1 ]
机构
[1] Radboud Univ Nijmegen, Dept Pathol, Med Ctr, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands
[3] Locat Rijnstate Hosp, Pathol DNA, Arnhem, Netherlands
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
immunoglobulin E; T-cell receptor; gene rearrangement; clonality assessment; NGS; pathology; B-CELL LYMPHOMA; POLYMERASE-CHAIN-REACTION; PERIPHERAL T-CELL; CLASSICAL HODGKIN LYMPHOMA; EPSTEIN-BARR-VIRUS; FOLLICULAR LYMPHOMA; GENE REARRANGEMENTS; SALIVARY-GLANDS; LATE RELAPSE; TRANSFORMATION;
D O I
10.3389/fonc.2023.1107171
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Clonality assessment using the unique rearrangements of immunoglobulin (IG) and T-cell receptor (TR) genes in lymphocytes is a widely applied supplementary test for the diagnosis of B-cell and T-cell lymphoma. To enable a more sensitive detection and a more precise comparison of clones compared with conventional clonality analysis based on fragment analysis, the EuroClonality NGS Working Group developed and validated a next-generation sequencing (NGS)-based clonality assay for detection of the IG heavy and kappa light chain and TR gene rearrangements for formalin-fixed and paraffin-embedded tissues. We outline the features and advantages of NGS-based clonality detection and discuss potential applications for NGS-based clonality testing in pathology, including site specific lymphoproliferations, immunodeficiency and autoimmune disease and primary and relapsed lymphomas. Also, we briefly discuss the role of T-cell repertoire of reactive lymphocytic infiltrations in solid tumors and B-lymphoma.
引用
收藏
页数:7
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