An Introduction to Analytical Challenges, Approaches, and Applications in Mass Spectrometry-Based Secretomics

被引：10

作者：

Knecht, Sascha ^{[1
,2
]}

Eberl, H. Christian ^{[1
]}

Kreisz, Norbert ^{[2
]}

Ugwu, Ukamaka Juliet ^{[2
]}

Starikova, Tatiana ^{[2
]}

Kuster, Bernhard ^{[2
]}

Wilhelm, Stephanie ^{[2
]}

机构：

[1] GlaxoSmithKline, Genom Sci, Omics Sci, Heidelberg, Germany

[2] Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany

来源：

MOLECULAR & CELLULAR PROTEOMICS | 2023年 / 22卷 / 09期

关键词：

NEWLY SYNTHESIZED PROTEINS; SERUM STARVATION; UNCONVENTIONAL SECRETION; PROTEOMIC QUANTIFICATION; MITOCHONDRIAL TRANSFER; HYDRAZIDE CHEMISTRY; CANCER BIOMARKERS; CELL SECRETOME; MUSCLE-CELLS; HUMAN PLASMA;

D O I：

10.1016/j.mcpro.2023.100636

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The active release of proteins into the extracellular space and the proteolytic cleavage of cell surface proteins are key processes that coordinate and fine-tune a multitude of physiological functions. The entirety of proteins that fulfill these extracellular tasks are referred to as the secretome and are of special interest for the investigation of biomarkers of disease states and physiological processes related to cell -cell communication. LC-MS-based proteomics approaches are a valuable tool for the comprehensive and unbiased characterization of this important subproteome. This review discusses procedures, opportunities, and limitations of mass spectrometry-based secretomics to better understand and navigate the complex analytical landscape for studying protein secretion in biomedical science.

引用

页数：19

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