MSR1 is not required for obesity-associated inflammation and insulin resistance in mice

被引:0
|
作者
Nance, Sierra A. [1 ,2 ]
Muir, Lindsey [3 ]
Delproprosto, Jennifer [2 ]
Lumeng, Carey N. [1 ,2 ]
机构
[1] Univ Michigan, Mol & Integrat Physiol, Med Sch, 109 Zina Pitcher Pl,2057 BSRB, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Pediat, Med Sch, 109 Zina Pitcher Pl,2057 BSRB, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Computat Med & Bioinformat, Med Sch, Ann Arbor, MI USA
基金
美国国家卫生研究院;
关键词
ADIPOSE-TISSUE; LOCAL PROLIFERATION; INTERLEUKIN-6; PROTECTION; ALPHA;
D O I
10.1038/s41598-023-29736-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Obesity induces a chronic inflammatory state associated with changes in adipose tissue macrophages (ATMs). Macrophage scavenger receptor 1 (MSR1) has been implicated in the regulation of adipose tissue inflammation and diabetes pathogenesis; however, reports have been mixed on the contribution of MSR1 in obesity and glucose intolerance. We observed increased MSR1 expression in VAT of obese diabetic individuals compared to non-diabetic and single nuclear RNA sequencing identified macrophage-specific expression of MSR1 in human adipose tissue. We examined male Msr1(-/-) (Msr1KO) and WT controls and observed protection from obesity and AT inflammation in non-littermate Msr1KO mice. We then evaluated obese littermate Msr1(+/-) (Msr1HET) and Msr1KO mice. Both Msr1KO mice and Msr1HET mice became obese and insulin resistant when compared to their normal chow diet counterparts, but there was no Msr1-dependent difference in body weight, glucose metabolism, or insulin resistance. Flow cytometry revealed no significant differences between genotypes in ATM subtypes or proliferation in male and female mice. We observed increased frequency of proliferating ATMs in obese female compared to male mice. Overall, we conclude that while MSR1 is a biomarker of diabetes status in human adipose tissue, in mice Msr1 is not required for obesity-associated insulin resistance or ATM accumulation.
引用
收藏
页数:10
相关论文
共 50 条
  • [31] Obesity-associated insulin resistance adversely affects skin function
    Aoki, Masafumi
    Murase, Takatoshi
    PLOS ONE, 2019, 14 (10):
  • [32] Osteopontin Is a Mediator of Obesity-Associated Hepatic Steatosis and Insulin Resistance
    Kiefer, Florian W.
    Zeyda, Maximilian
    Neschen, Susanne
    Gollinger, Karina
    Pfau, Birgit
    Neuhofer, Angelika
    Weichhart, Thomas
    Kenner, Lukas
    Stulnig, Thomas M.
    DIABETES, 2009, 58 : A437 - A437
  • [33] Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis
    Deveaux, Vanessa
    Cadoudal, Thomas
    Ichigotani, Yasukatsu
    Teixeira-Clerc, Fatima
    Louvet, Alexandre
    Manin, Sylvie
    Tran-Van Nhieu, Jeanne
    Belot, Marie Pierre
    Zimmer, Andreas
    Even, Patrick
    Cani, Patrice D.
    Knauf, Claude
    Burcelin, Remy
    Bertola, Adeline
    Le Marchand-Brustel, Yannick
    Gual, Philippe
    Mallat, Ariane
    Lotersztajn, Sophie
    PLOS ONE, 2009, 4 (06):
  • [34] A major role of insulin in promoting obesity-associated adipose tissue inflammation
    Pedersen, David J.
    Guilherme, Adilson
    Danai, Laura V.
    Heyda, Lauren
    Matevossian, Anouch
    Cohen, Jessica
    Nicoloro, Sarah M.
    Straubhaar, Juerg
    Noh, Hye Lim
    Jung, DaeYoung
    Kim, Jason K.
    Czech, Michael P.
    MOLECULAR METABOLISM, 2015, 4 (07): : 507 - 518
  • [35] Muscle Inflammation Is Associated with Obesity and Insulin Resistance
    Varma, Vijayalakshmi
    Yao-Borengasser, Aiwei
    Rasouli, Neda
    Nolen, Greg T.
    Phanavanh, Bounleut
    Starks, Tasha
    Gurley, Cathy
    Simpson, Pippa
    McGehee, Robert E.
    Kern, Philip A.
    Peterson, Charlotte A.
    DIABETES, 2009, 58 : A392 - A392
  • [36] Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
    Wu, Lan
    Van Kaer, Luc
    ADIPOCYTE, 2013, 2 (01) : 12 - 16
  • [37] Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis
    Bae, Sumin
    Ullah, Irfan
    Beloor, Jagadish
    Lim, Jaeyeoung
    Chung, Kunho
    Yi, Yujong
    Kang, Eunhwa
    Yun, Gyeongju
    Rhim, Taiyoun
    Lee, Sang-Kyung
    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2024, 135 : 434 - 443
  • [38] Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance
    Perfield, James W., II
    Lee, Yunkyoung
    Shulman, Gerald I.
    Samuel, Varman T.
    Jurczak, Michael J.
    Chang, Eugene
    Xie, Chen
    Tsichlis, Phillip N.
    Obin, Martin S.
    Greenberg, Andrew S.
    DIABETES, 2011, 60 (04) : 1168 - 1176
  • [39] Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance
    Harmon, Daniel B.
    Srikakulapu, Prasad
    Kaplan, Jennifer L.
    Oldham, Stephanie N.
    McSkimming, Chantel
    Garmey, James C.
    Perry, Heather M.
    Kirby, Jennifer L.
    Prohaska, Thomas A.
    Gonen, Ayelet
    Hallowell, Peter
    Schirmer, Bruce
    Tsimikas, Sotirios
    Taylor, Angela M.
    Witztum, Joseph L.
    McNamara, Coleen A.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (04) : 682 - 691
  • [40] Therapy with resveratrol attenuates obesity-associated allergic airway inflammation in mice
    Andre, Diana Majolli
    Calixto, Marina Ciarallo
    Sollon, Carolina
    Alexandre, Eduardo Costa
    Leiria, Luiz O.
    Tobar, Natalia
    Anhe, Gabriel Forato
    Antunes, Edson
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 38 : 298 - 305