Subgroup analysis of patients (pts) with HER2-low metastatic breast cancer (mBC) with brain metastases (BMs) at baseline from DESTINY-Breast04, a randomized phase III study of trastuzumab deruxtecan (T-DXd) vs treatment of physician's choice (TPC)

被引:8
|
作者
Tsurutani, J. [1 ]
Jacot, W. [2 ]
Yamashita, T. [3 ]
Riaz, F. [4 ]
Yerushalmi, R. [5 ]
Im, S-A. [6 ]
Niikura, N. [7 ]
Halser-Strub, U. [8 ]
Cortes, J. [9 ,10 ]
Wennstig, A-K. [11 ]
Chae, Y. [12 ]
Wang, X. [13 ]
Li, W. [14 ]
Simon, H. [15 ]
Masci, G. [16 ]
Tamburini, E. [17 ]
Aguilar, C. Orbegoso [18 ]
Tecson, K. [19 ]
Yung, L. [20 ]
Modi, S. [21 ]
机构
[1] Showa Univ Hosp, Adv Canc Translat Res Inst, Tokyo, Japan
[2] Inst Canc Montpellier, Med Oncol, Montpellier, France
[3] Kanagawa Canc Ctr, Breast Surg & Oncol, Yokohama, Kanagawa, Japan
[4] Stanford Sch Med, Med Oncol, Stanford, CA USA
[5] Tel Aviv Univ, Inst Oncol, Davidoff Ctr, Rabin Med Ctr, Petah Tiqwa, Israel
[6] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea
[7] Tokai Univ, Breast Oncol, Sch Med, Isehara, Kanagawa, Japan
[8] Kantonsspital St Gallen, Breast Ctr, St Gallen, Switzerland
[9] Int Breast Canc Ctr, Oncol, Pangaea Oncol, Quironsalud Grp, Madrid, Spain
[10] Int Breast Canc Ctr, Oncol, Pangaea Oncol, Quironsalud Grp, Barcelona, Spain
[11] Sundsvall Hosp, Oncol, Sundsvall, Sweden
[12] Kyungpook Natl Univ, Med Oncol, Chilgok Hosp, Daegu, South Korea
[13] Zhejiang Canc Hosp, Med Oncol, Canc Res Inst, Hangzhou, Peoples R China
[14] First Hosp Jilin Univ, Tumor Ctr, Changchun, Jilin, Peoples R China
[15] CHU Brest, Oncol, Hop Morvan, Inst Cancerol & Hematol, Brest, France
[16] Humanitas Clin Res Hosp Rozzano, Med Oncol, Rozzano, MI, Italy
[17] Pia Fdn Cardinale G Panico Hosp, Oncol & Palliat Care, Tricase, Italy
[18] Daiichi Sankyo France SAS, Global Oncol R&D, Rueil Malmaison, France
[19] Daiichi Sankyo Inc, Evidence Generat, Basking Ridge, NJ USA
[20] Daiichi Sankyo Inc, Global Oncol R&D, Basking Ridge, NJ USA
[21] Mem Sloan Kettering Canc Ctr, Med, New York, NY USA
关键词
D O I
10.1016/j.annonc.2023.09.565
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
388P
引用
收藏
页码:S342 / S343
页数:2
相关论文
共 50 条
  • [21] Patient-reported outcomes (PROs) from DESTINY-Breast03, a randomized phase III study of trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (MBC)
    Curigliano, G.
    Dunton, K.
    Rosenlund, M.
    Janek, M.
    Cathcart, J.
    Liu, Y.
    Fasching, P. A.
    Iwata, H.
    ANNALS OF ONCOLOGY, 2022, 33 : S196 - S197
  • [22] Effects of trastuzumab deruxtecan (T-DXd) vs choice of chemotherapy (TPC) on patient-reported outcomes (PROs) in hormone receptor-positive, HER2-low or HER2-ultralow metastatic breast cancer (mBC): Results from DESTINY-Breast06
    Hu, X.
    Curigliano, G.
    Yonemori, K.
    Bardia, A.
    Barrios, C. H. E.
    Sohn, J.
    Levy, C.
    Jacot, W.
    Tsurutani, J.
    Mezei, K.
    de Climens, A. Roborel
    Wu, X.
    Begbie, N.
    Mbanya, Z.
    Dent, R. A.
    ANNALS OF ONCOLOGY, 2024, 35 : 1214 - 1215
  • [24] Pooled analysis by best confirmed response to trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+metastatic breast cancer (mBC) from DESTINY-Breast-01,-02, and-03
    Saura, Cristina
    Cortes, Javier
    Modi, Shanu
    Kim, Sung-Bae
    Hamilton, Erika P.
    Hurvitz, Sara A.
    Krop, Ian E.
    Curigliano, Giuseppe
    Iwata, Hiroji
    Im, Seock-Ah
    Herbolsheimer, Pia Maarit
    Karnoub, Maha
    Gambhire, Dhiraj
    Egorov, Anton
    Andre, Fabrice
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [25] Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2+advanced/metastatic breast cancer (mBC) with or without brain metastases (BM): DESTINYBreast-12 primary results
    Lin, N.
    Ciruelos, E. M.
    Jerusalem, G.
    Mueller, V.
    Niikura, N.
    Viale, G.
    Bartsch, R.
    Kurzeder, C.
    Connolly, R.
    Baron-Hay, S. E.
    Cortes, M. Gion
    Guarneri, V.
    Bianchini, G.
    Wildiers, H.
    Escriva-de-Romani, S.
    Prahladan, M.
    Bridge, H.
    Verma, S.
    Harbeck, N.
    ANNALS OF ONCOLOGY, 2024, 35 : 1211 - 1212
  • [26] Trastuzumab deruxtecan (T-DXd) in patients with HER2-positive metastatic breast cancer (MBC): Updated survival results from a phase II trial (DESTINY-Breast01)
    Saura Manich, C.
    Modi, S.
    Krop, I.
    Park, Y. H.
    Kim, S-B.
    Tamura, K.
    Andre, F.
    Iwata, H.
    Ito, Y.
    Tsurutani, J.
    Sohn, J.
    Lee, C.
    Liu, Y.
    Cathcart, J.
    Singh, J.
    Yamashita, T.
    ANNALS OF ONCOLOGY, 2021, 32 : S485 - S486
  • [27] An age-specific pooled analysis of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (mBC) from DESTINY-Breast01,-02, and-03
    Krop, Ian E.
    Wildiers, Hans
    Hurvitz, Sara A.
    Cortes, Javier
    Im, Seock-Ah
    Iwata, Hiroji
    Andre, Fabrice
    Saura, Cristina
    Modi, Shanu
    Kim, Sung-Bae
    Egorov, Anton
    Mathias, Elton
    Cathcart, Jillian
    Cagnazzo, Antonio
    Cheng, Yingkai
    Park, Yeon Hee
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [28] Updated results from DESTINY-breast01, a phase 2 trial of trastuzumab deruxtecan (T-DXd) in HER2 positive metastatic breast cancer
    Modi, Shanu
    Saura, Cristina
    Yamashita, Toshinari
    Park, Yeon Hee
    Kim, Sung-Bae
    Tamura, Kenji
    Andre, Fabrice
    Iwata, Hiroji
    Ito, Yoshinori
    Tsurutani, Junji
    Sohn, Joohyuk
    Denduluri, Neelima
    Perrin, Christophe
    Aogi, Kenjiro
    Tokunaga, Eriko
    Im, Seock-Ah
    Lee, Keun Seok
    Hurvitz, Sara A.
    Cortes, Javier
    Lee, Caleb
    Liu, Yali
    Zhang, Lin
    Shahidi, Javad
    Yver, Antoine
    Baselga, Jose
    Krop, Ian E.
    CANCER RESEARCH, 2021, 81 (04)
  • [29] Trastuzumab Deruxtecan in HER2-Positive Metastatic Breast Cancer Patients with Brain Metastases: A DESTINY-Breast01 Subgroup Analysis
    Jerusalem, Guy
    Park, Yeon Hee
    Yamashita, Toshinari
    Hurvitz, Sara A.
    Modi, Shanu
    Andre, Fabrice
    Krop, Ian E.
    Farre, Xavier Gonzalez
    You, Benoit
    Saura, Cristina
    Kim, Sung-Bae
    Osborne, Cynthia R.
    Murthy, Rashmi K.
    Gianni, Lorenzo
    Takano, Toshimi
    Liu, Yali
    Cathcart, Jillian
    Lee, Caleb
    Perrin, Christophe
    CANCER DISCOVERY, 2022, 12 (12) : 2754 - 2762
  • [30] Trastuzumab deruxtecan (T-DXd) versus trastuzumab emtansine (T-DM1) in patients (pts) with HER2-positive (HER2+) unresectable and/or metastatic breast cancer (mBC): Safety follow-up of the randomized, phase 3 study DESTINY-Breast03.
    Hamilton, Erika P.
    Petry Helena, Vanessa Bragaia
    Yeo, Bragaia Winnie
    Kim, Sung-Bae
    Bianchini, Giampaolo
    Yamashita, Toshinari
    Yonemori, Kan
    Inoue, Kenichi
    Curigliano, Giuseppe
    Hurvitz, Sara A.
    Cortes, Javier
    Iwata, Hiroji
    Cathcart, Jillian
    Liu, Yali
    Lee, Caleb C.
    Bako, Emarjola
    Kim, Rachel
    Im, Seock-Ah
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)