Examining the mu-opioid receptor bias of fentanyl and 2-benzylbenzimidazole opioids in clandestine drug markets

被引:0
|
作者
Tsai, Meng-Hua M. [1 ]
Chen, Li [1 ]
Baumann, Michael H. [1 ]
Shi, Lei [1 ]
机构
[1] NIDA Intramural Res Program, Baltimore, MD USA
关键词
D O I
10.1124/jpet.122.156170
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
84
引用
收藏
页数:1
相关论文
共 50 条
  • [31] The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception
    Sanchez-Blazquez, Pilar
    Cortes-Montero, Elsa
    Rodriguez-Munoz, Maria
    Merlos, Manuel
    Garzon-Nino, Javier
    MOLECULAR BRAIN, 2020, 13 (01)
  • [32] Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray
    Roychowdhury, SM
    Fields, HL
    NEUROSCIENCE, 1996, 74 (03) : 863 - 872
  • [33] Synthesis, biological, and structural explorations of a series of mu-opioid receptor (MOR) agonists with high G protein signaling bias
    Yang, Yifei
    Wang, Yonghai
    Zuo, Aixia
    Li, Chunmei
    Wang, Wenyan
    Jiang, Wanglin
    Zhang, Xiaochen
    Che, Xin
    Zhang, Yang
    Wu, Wentao
    Cen, Xiaobo
    Wang, Hongbo
    Tian, Jingwei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 228
  • [34] Association of Mu-Opioid Receptor(MOR) Expression and Opioids Requirement With Survival in Patients With Stage I-III Pancreatic Ductal Adenocarcinoma
    Zhang, Hao
    Qu, Mengdi
    Gorur, Aysegul
    Sun, Zhirong
    Cata, Juan P.
    Chen, Wankun
    Miao, Changhong
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [35] Comparison of the mu-opioid receptor antagonists methocinnamox (MCAM) and naloxone to reverse the ventilatory-depressant effects of fentanyl and heroin in male rats
    Hiranita, Takato
    Ho, Nicholas P.
    France, Charles P.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [36] Comparison of the mu-opioid receptor antagonists methocinnamox (MCAM) and naloxone to reverse the ventilatory-depressant effects of fentanyl, heroin, and carfentanil in rat
    Hiranita, T.
    Ho, N. P.
    France, C. P.
    ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 47 : 598 - 598
  • [37] NICOTINE PROTECTS AGAINST MU-OPIOID RECEPTOR ANTAGONISM BY BETA-FUNALTREXAMINE - EVIDENCE FOR NICOTINE-INDUCED RELEASE OF ENDOGENOUS OPIOIDS IN BRAIN
    DAVENPORT, KE
    HOUDI, AA
    VANLOON, GR
    NEUROSCIENCE LETTERS, 1990, 113 (01) : 40 - 46
  • [38] FAST, LOCAL SIGNAL-TRANSDUCTION BETWEEN THE MU-OPIOID RECEPTOR AND CA2+ CHANNELS
    WILDING, TJ
    WOMACK, MD
    MCCLESKEY, EW
    JOURNAL OF NEUROSCIENCE, 1995, 15 (05): : 4124 - 4132
  • [39] The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit
    Champion, HC
    Zadina, JE
    Kastin, AJ
    Hackler, L
    Ge, LJ
    Kadowitz, PJ
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (03) : 567 - 570
  • [40] A20 enhances mu-opioid receptor function by inhibiting beta-arrestin2 recruitment
    Shao, Shuai
    Sun, Yi
    Zhang, Yijia
    Tian, Xiangyun
    Li, Yulei
    Tan, Bo
    Su, Ruibin
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 528 (01) : 127 - 133