Defluoroalkylation of gem-Difluoroalkenes with Alcohols via C-F/C-H Coupling

被引：2
|
作者：
Xia, Congjian [1 ]
Hu, Haiyang [2 ]
Xu, Wengang [1 ]
Yang, Baokai [1 ]
Shao, Qi [2 ]
Wu, Mingbo [1 ,2 ]
机构：
[1] China Univ Petr East China, Coll New Energy, State Key Lab Heavy Oil Proc, Qingdao 266580, Peoples R China
[2] China Univ Petr East China, Coll Chem & Chem Engn, Qingdao 266580, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 26卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
HYDROGEN-ATOM TRANSFER; BOND FUNCTIONALIZATIONS; MONOFLUOROALKENYLATION; TRIFLUOROMETHYLATION; DEFLUOROBORYLATION; PHOTOCATALYSIS; CARBOXYLATION; FLUOROOLEFINS; ALKYLATION; ACTIVATION;
D O I：
10.1021/acs.orglett.3c03982
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A feasible and effective method to synthesize alpha-fluoroalkenyl alcohols was reported. With the cooperation of photoredox and hydrogen atom transfer (HAT) processes, defluoroalkylations of gem-difluoroalkenes occurred smoothly with alcohols under visible-light irradiation. Notably, the protocols feature broad scopes, mild conditions, and validity for the late-stage functionalization of bioactive molecule derivatives. Mechanistic studies suggested that the reaction occurred through the radical coupling of the alkyl radical and the fluoroalkenyl radical.
引用
收藏
页码：310 / 314
页数：5
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