Discovery of GSBR-1290, a Highly Potent, Orally Available, Novel Small Molecule GLP-1 Receptor Agonist

被引:1
|
作者
Mao, Ting
Meng, Qinghua
Zhang, Haizhen
Zhang, Jinqiang J.
Shi, Songting
Guan, Zhibo
Jiang, Xinglong
Zhang, Fang
Lei, Hui
Lin, Xichen
机构
关键词
D O I
10.2337/db23-760-P
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
760-P
引用
收藏
页数:2
相关论文
共 50 条
  • [21] A Phase 1b/2a Study of the Safety and Tolerability of GSBR-1290, a Novel Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA), in Healthy Overweight/Obese Volunteers (HOV) and Participants with Type 2 Diabetes Mellitus (T2DM)
    Coll, Blai
    Zhang, Jinqiang
    Chen, Libo
    Ibarra, Lani
    Yue, Huibin
    Barth, Aline
    Bach, Mark A.
    DIABETES, 2024, 73
  • [22] Discovery of a novel small molecule agonist scaffold for the APJ receptor
    Narayanan, Sanju
    Maitra, Rangan
    Deschamps, Jeffery R.
    Bortoff, Katherine
    Thomas, James B.
    Zhang, Yanyan
    Warner, Keith
    Vasukuttan, Vineetha
    Decker, Ann
    Runyon, Scott P.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (16) : 3758 - 3770
  • [23] Discovery of a potent and long-acting Xenopus GLP-1-based GLP-1/glucagon/Y2 receptor triple agonist
    Yuan, Yongliang
    Yan, Zhiming
    Lao, Qifang
    Jiang, Neng
    Wu, Shuangmin
    Lu, Qinpei
    Han, Jing
    Zhao, Songfeng
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 247
  • [24] Discovery of novel and highly potent small molecule inhibitors of chemokine receptor CXCR4
    Fang, Xiong
    Meng, Qian
    Fang, Xiao
    Zhu, Siyu
    Huang, Yazi
    An, Jing
    Xu, Yan
    Huang, Ziwei
    CANCER RESEARCH, 2019, 79 (13)
  • [25] Discovery of novel, highly potent and selective small molecule farnesoid X receptor (FXR) agonists
    Richter, Hans G. F.
    Benson, Gregory M.
    Bleicher, Konrad H.
    Blum, Denise
    Chaput, Evelyne
    Clemann, Nicole
    Feng, Song
    Gardes, Christophe
    Grether, Uwe
    Hartman, Peter
    Kuhn, Bernd
    Martin, Rainer E.
    Plancher, Jean-Marc
    Rudolph, Markus
    Schuler, Franz
    Taylor, Sven
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [26] Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel oral small molecule GLP-1 receptor agonist (HRS-7535) in healthy subjects
    Wu, J.
    Hu, W.
    Du, Y.
    Zhang, Q.
    Zhou, R.
    Zhang, Q.
    Qin, H.
    Ye, Z.
    Xu, Y.
    Feng, S.
    Shu, C.
    Shen, Y.
    Fan, Y.
    DIABETOLOGIA, 2023, 66 (SUPPL 1) : S316 - S317
  • [27] Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52
    Setoh, Masaki
    Ishii, Naoki
    Kono, Mitsunori
    Miyanohana, Yuhei
    Shiraishi, Eri
    Harasawa, Toshiya
    Ota, Hiroyuki
    Odani, Tomoyuki
    Kanzaki, Naoyuki
    Aoyama, Kazunobu
    Hamada, Teruki
    Kori, Masakuni
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (12) : 5226 - 5237
  • [28] Discovery of the first potent and orally available agonist of the orphan G protein-coupled receptor 52
    Setoh, Masaki
    Ishii, Naoki
    Kono, Mitsunori
    Miyanohana, Yuhei
    Shiraishi, Eri
    Harasawa, Toshiya
    Ota, Hiroyuki
    Odani, Tomoyuki
    Kanzaki, Naoyuki
    Aoyama, Kazunobu
    Hamada, Teruki
    Kori, Masakuni
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [29] Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
    Zhao, Qian
    Dong, Jiale
    Liu, Han
    Chen, Hui
    Yu, Huan
    Ye, Shuyin
    Yu, Shuangjin
    Li, Yu
    Qiu, Longhui
    Song, Nazi
    Xu, Hongjiao
    Liu, Qi
    Luo, Zhiteng
    Li, Yuyi
    Wang, Rui
    Chen, Guodong
    Jiang, Xianxing
    ACTA PHARMACEUTICA SINICA B, 2024, 14 (03) : 1283 - 1301
  • [30] Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
    Qian Zhao
    Jiale Dong
    Han Liu
    Hui Chen
    Huan Yu
    Shuyin Ye
    Shuangjin Yu
    Yu Li
    Longhui Qiu
    Nazi Song
    Hongjiao Xu
    Qi Liu
    Zhiteng Luo
    Yuyi Li
    Rui Wang
    Guodong Chen
    Xianxing Jiang
    Acta Pharmaceutica Sinica B, 2024, 14 (03) : 1283 - 1301