Subcutaneous Implantable Cardioverter-Defibrillators in Patients With Congenital Heart Disease

被引：3

作者：

Waldmann, Victor ^{[1
,2
,3
,4
,38
]}

Marquie, Christelle ^{[5
]}

Bessiere, Francis ^{[6
,7
]}

Perrot, David ^{[1
,4
]}

Anselme, Frederic ^{[8
]}

Badenco, Nicolas ^{[9
]}

Barra, Sergio ^{[1
,10
]}

Bertaux, Geraldine ^{[11
]}

Blangy, Hugues ^{[12
]}

Bordachar, Pierre ^{[13
]}

Boveda, Serge ^{[14
]}

Chauvin, Michel ^{[15
,16
]}

Clementy, Nicolas ^{[17
]}

Clerici, Gael ^{[18
]}

Combes, Nicolas

Defaye, Pascal ^{[19
]}

Deharo, Jean-Claude ^{[20
,21
]}

Durand, Philippe ^{[22
]}

Duthoit, Guillaume ^{[9
]}

Eschalier, Romain ^{[23
,24
]}

Fauchier, Laurent ^{[17
]}

Garcia, Rodrigue ^{[25
,26
]}

Geoffroy, Olivier ^{[18
]}

Gitenay, Edouard ^{[27
]}

Gourraud, Jean-Baptiste ^{[28
]}

Guenancia, Charles ^{[11
]}

Iserin, Laurence ^{[2
]}

Jacon, Peggy ^{[19
]}

Jesel-Morel, Laurence ^{[29
]}

Kerkouri, Fawzi ^{[1
,30
]}

Klug, Didier ^{[5
]}

Koutbi, Linda ^{[20
,21
]}

Labombarda, Fabien ^{[31
]}

Ladouceur, Magalie ^{[1
,2
]}

Laurent, Gabriel ^{[11
]}

Leclercq, Christophe ^{[32
]}

Maille, Baptiste ^{[20
,21
]}

Maltret, Alice ^{[33
]}

Massoulie, Gregoire ^{[23
,24
]}

Mondoly, Pierre ^{[34
]}

Ninni, Sandro ^{[5
]}

Ollitrault, Pierre ^{[31
]}

Pasquie, Jean-Luc ^{[35
]}

Pierre, Bertrand ^{[17
]}

Pujadas, Penelope ^{[36
]}

Champ-Rigot, Laure ^{[31
]}

Sacher, Frederic ^{[13
]}

Sadoul, Nicolas ^{[12
]}

Schatz, Alexandre ^{[29
]}

Winum, Pierre ^{[37
]}

机构：

[1] Univ Paris, Paris Cardiovasc Res Ctr, INSERM, Paris, France

[2] Hop Europeen Georges Pompidou, Adult Congenital Heart Dis Med Surg Unit, Paris, France

[3] Hop Necker Enfants Malad, Pediat & Congenital Med Surg Unit, Paris, France

[4] Hop Europeen Georges Pompidou, Cardiac Electrophysiol Unit, Paris, France

[5] CHU Lille, Lille, France

[6] Univ Lyon, INSERM LabTau, Lyon, France

[7] Hosp Civils Lyon, Hop Louis Pradel, Lyon, France

[8] CHU Rouen, Rouen, France

[9] Hop La Pitie Salpetriere, Paris, France

[10] Hosp Luz Arrabida, Cardiol Dept, Vila Nova De Gaia, Portugal

[11] CHU Dijon Bourgogne, Dijon, France

[12] CHU Nancy, Nancy, France

[13] CHU Bordeaux, Bordeaux, France

[14] Clin Pasteur, Toulouse, France

[15] ICS HENA Strasbourg, Strasbourg, France

[16] Clin Orangerie, Strasbourg, France

[17] CHU Tours, Tours, France

[18] CHU La Reunion, St Pierre, France

[19] CHU Grenoble Alpes, Grenoble, France

[20] Ctr Hosp Univ La Timone, Assistance Publ Hop Marseille, Serv Cardiol, Marseille, France

[21] Aix Marseille Univ, C2VN, Marseille, France

[22] Ctr Med Chirurg Arnault Tzanck, St Laurent Du Var, France

[23] CHU Clermont Ferrand, Cardiol Dept, F-63000 Clermont Ferrand, France

[24] Univ Clermont Auvergne, Inst Pascal, CHU Clermont Ferrand, CNRS,SIGMA Clermont, F-63000 Clermont Ferrand, France

[25] Univ Hosp Poitiers, Cardiol Dept, Poitiers, France

[26] Univ Hosp Poitiers, Ctr Invest Clin 1402, Poitiers, France

[27] Hop St Joseph, Marseille, France

[28] CHU Nantes, Nantes, France

[29] CHU Strasbourg, Strasbourg, France

[30] Univ Hosp Brest, Brest, France

[31] CHU Caen, Caen, France

[32] CHRU Rennes, Rennes, France

[33] Hop Marie Lannelongue, Le Plessis Robinson, France

[34] CHU Toulouse, Toulouse, France

[35] Univ Montpellier, PhyMedExp, INSERM, CNRS, Montpellier, France

[36] Hop Prive Franciscaines, Nimes, France

[37] CHU Nimes, Nimes, France

[38] Hop Europeen Georges Pompidou, Serv Cardiol, 20-40 Rue Leblanc, F-75908 Paris 15, France

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2023年 / 82卷 / 07期

关键词：

KEY WORDS congenital heart disease; implantable cardioverter defibrillator; sudden death; ventricular arrhythmia; PEDIATRIC CARDIAC-SURGERY; TETRALOGY; DEATH; FALLOT; ADULTS;

D O I：

10.1016/j.jacc.2023.05.057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Very few data have been published on the use of subcutaneous implantable cardioverter-defibrillators (S-ICDs) in patients with congenital heart disease (CHD). OBJECTIVES The aim of this study was to analyze outcomes associated with S-ICDs in patients with CHD. METHODS This nationwide French cohort including all patients with an S-ICD was initiated in 2020 by the French Institute of Health and Medical Research. Characteristics at implantation and outcomes were analyzed in patients with CHD. RESULTS From October 12, 2012, to December 31, 2019, among 4,924 patients receiving an S-ICD implant in 150 centers, 101 (2.1%) had CHD. Tetralogy of Fallot, univentricular heart, and dextro-transposition of the great arteries represented almost one-half of the population. Patients with CHD were significantly younger (age 37.1 +/- 15.4 years vs 50.1 +/- 14.9 years; P < 0.001), more frequently female (37.6% vs 23.0%; P < 0.001), more likely to receive an S-ICD for secondary prevention (72.3% vs 35.9%; P < 0.001), and less likely to have severe systolic dysfunction of the systemic ventricle (28.1% vs 53.1%; P < 0.001). Over a mean follow-up period of 1.9 years, 16 (15.8%) patients with CHD received at least 1 appropriate shock, with all shocks successfully terminating the ventricular arrhythmia. The crude risk of appropriate S-ICD shock was twice as high in patients with CHD compared with non-CHD patients (annual incidences of 9.0% vs 4.4%; HR: 2.1; 95% CI: 1.3-3.4); however, this association was no longer significant after propensity matching (especially considering S-ICD indication, P = 0.12). The burden of all complications (HR: 1.2; 95% CI: 0.7-2.1; P = 0.4) and inappropriate shocks (HR: 0.9; 95% CI: 0.4-2.0; P = 0.9) was comparable in both groups. CONCLUSIONS In this nationwide study, patients with CHD represented 2% of all S-ICD implantations. Our findings emphasize the effectiveness and safety of S-ICD in this particularly high-risk population. (S-ICD French Cohort Study [HONEST]; NCT05302115) (J Am Coll Cardiol 2023;82:590-599) (c) 2023 by the American College of Cardiology Foundation.

引用

页码：590 / 599

页数：10

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