Towards disease modification in osteoarthritis

被引：2
|
作者：
Dell'Accio, Francesco [1 ]
De Bari, Cosimo [2 ]
机构：
[1] Queen Mary Univ London, William Harvey Res Inst, London, England
[2] Univ Aberdeen, Ctr Arthrit & Musculoskeletal Hlth, Aberdeen, Scotland
来源：
OSTEOARTHRITIS AND CARTILAGE | 2023年 / 31卷 / 09期
关键词：
LIPID-METABOLISM; INHIBITION; ANGPTL3;
D O I：
10.1016/j.joca.2023.05.002
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
In December 2022, Gerwin et al published in Nature Medicine that the C-terminal portion of angiopoietin-like 3, called LNA043, has chondroprotective and cartilage-regenerative properties. Molecular data from an experimental medicine phase I study suggested potential efficacy in humans. Here, we respond to and complement a commentary from Vincent and Conaghan and discuss unresolved issues and the potential of this molecule as a disease-modifying osteoarthritis drug. (c) 2023 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
引用
收藏
页码：1154 / 1155
页数：2
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