The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances

被引：1
|
作者：
Li, Lili [1 ]
Zhao, Jianghui [1 ]
Ma, Fengcang [1 ]
He, Daihua [1 ]
Liu, Ping [1 ]
Li, Wei [1 ]
Zhang, Ke [1 ]
Chen, Xiaohong [1 ]
Song, Lin [2 ]
机构：
[1] Univ Shanghai Sci & Technol, Sch Mat & Chem, Shanghai 200093, Peoples R China
[2] China Med Device Test Ctr, Pass Device Test Ctr, Shanghai 201318, Peoples R China
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2023年 / 34卷 / 10期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
All Open Access; Gold;
D O I：
10.1007/s10856-023-06755-x
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8.
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页数：6
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