Using the supercritical carbon dioxide as the solvent of Nystatin: Studying the effect of co-solvent, experimental and correlating

The solubility of Nystatin in supercritical CO2 at 308-338 K and 12-30 MPa, with or without a co-solvent, was determined. Additionally, the effect of utilizing ethanol as a co-solvent was studied. In addition, after deter-mining the experimental solubility data, empirical and semi-empirical methods were used to model the studied systems. Nystatin's solubility in the binary system was measured to be between 0.40 x 10-6 to 1.20 x 10-5, whereas its solubility values in the ternary system was between 0.9 x 10-5 and 1.16 x 10-4. On the basis of the results obtained, it was determined that the addition of a co-solvent can significantly increase the solubility of Nystatin. The highest solubility of Nystatin was observed in the Nystatin-Ethanol-CO2 system at 338 K and 30 MPa, which was 24 times greater than the solubility of Nystatin in supercritical carbon dioxide at the same temperature and pressure. Moreover, it was demonstrated that all evaluated models are capable of correlating the solubility data of the investigated samples.