The Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in Rheumatoid Arthritis

被引：0

作者：

Abaszadeh, Amir ^{[1
]}

Salehi, Oveis ^{[2
]}

Badali, Ahmadreza ^{[3
]}

Lavanmardi, Dorsa ^{[4
]}

Sarlak, Alireza ^{[5
]}

Lotfalian, Azam ^{[6
]}

Poudineh, Maryam ^{[1
,7
,8
]}

机构：

[1] Ilam Univ, Sch Med, Ilam, Iran

[2] Univ Tehran Med Sci, Tehran, Iran

[3] Tabriz Univ Med Sci, Res Ctr Connect Tissue Dis, Tabriz, Iran

[4] Fars Stem Cell Res Inst, Shiraz, Fars, Iran

[5] Hamadan Univ Med Sci, Student Res Comm, Sch Med, Hamadan, Iran

[6] Shahid Sadoughi Univ Med Sci, Dept Biol & Anat Sci, Yazd, Iran

[7] Mashhad Azad Univ, Sch Med, Mashhad, Iran

[8] Islamic Azad Univ, Sch Med, Mashhad Branch, Mashhad, Iran

来源：

GALEN MEDICAL JOURNAL | 2023年 / 12卷

关键词：

Rheumatoid Arthritis; Mesenchymal Stem Cell; Extracellular Vesicle; Exosome; STEM-CELLS; THERAPY; AMELIORATION; EXOSOMES; SAFETY;

D O I：

10.31661/gmj.v12i.3075

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There is presently no cure for the chronic inflammatory disease rheumatoid arthritis (RA), which affects the joints and other organs. Mesenchymal stem/stromal cells (MSCs) are adult stem cells that are widely studied in inflammatory diseases. Several studies have shown the therapeutic effects of MSCs in preclinical and clinical RA. However, there are a few concerns regarding the use of MSCs, such as immune rejection and malignancy. Since MSCs exert their potential effects in a paracrine manner, more attention has been paid to their extracellular vesicles (MSC-EVs). In the current study, we reviewed the application of MSCs and their EVs in RA. A better understanding of the mechanisms driving MSC and MSC-EVs in RA offers insight into possible treatment options for RA. [GMJ.2023

引用

页数：7

共 50 条

[1] Therapeutic Effects of Mesenchymal/Stromal Stem Cells and Their Derived Extracellular Vesicles in Rheumatoid Arthritis
Tsiapalis, Dimitrios
Floudas, Achilleas
Tertel, Tobias
Boerger, Verena
Giebel, Bernd
Veale, Douglas J.
Fearon, Ursula
O'Driscoll, Lorraine
STEM CELLS TRANSLATIONAL MEDICINE, 2023, 12 (12) : 849 - 862
[2] Cellular and Molecular Targets of Extracellular Vesicles from Mesenchymal Stem/Stromal Cells in Rheumatoid Arthritis
Jose Alcaraz, Maria
Isabel Guillen, Maria
STEM CELLS TRANSLATIONAL MEDICINE, 2022, 11 (12) : 1177 - 1185
[3] Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis
Liu, Huan
Li, Ruicen
Liu, Tao
Yang, Leiyi
Yin, Geng
Xie, Qibing
FRONTIERS IN IMMUNOLOGY, 2020, 11
[4] A comprehensive review on the role of mesenchymal stromal/stem cells in the management of rheumatoid arthritis
Pignatti, Elisa
Maccaferri, Monia
Pisciotta, Alessandra
Carnevale, Gianluca
Salvarani, Carlo
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2024, 20 (05) : 463 - 484
[5] The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis
Bakinowska, Estera
Bratborska, Aleksandra Wiktoria
Kielbowski, Kajetan
Cmil, Maciej
Biniek, Wojciech Jerzy
Pawlik, Andrzej
CELLS, 2024, 13 (11)
[6] The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation
Bruno, Stefania
Deregibus, Maria Chiara
Camussi, Giovanni
IMMUNOLOGY LETTERS, 2015, 168 (02) : 154 - 158
[7] The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis
Gilazieva, Zarema
Ponomarev, Aleksei
Rizvanov, Albert
Solovyeva, Valeriya
BIOLOGY-BASEL, 2022, 11 (06):
[8] Mesenchymal stem/stromal cells release different subtypes of extracellular vesicles
Ferrer-Tur, R.
Goergens, A.
Boerger, V.
Horn, P. A.
Giebel, B.
TRANSFUSION MEDICINE AND HEMOTHERAPY, 2017, 44 : 86 - 87
[9] Role of extracellular vesicles in rheumatoid arthritis
Fu, Haitao
Hu, Die
Zhang, Licheng
Tang, Peifu
MOLECULAR IMMUNOLOGY, 2018, 93 : 125 - 132
[10] Role of mesenchymal stem cells secretome in rheumatoid arthritis
Karhade, Juilee
Behera, Shubhanath
Pandey, Garima
Prasad, Arpita
Wani, Mohan
JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 306 - 306

← 1 2 3 4 5 →