The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

被引:2
|
作者
Bakinowska, Estera [1 ]
Bratborska, Aleksandra Wiktoria [2 ]
Kielbowski, Kajetan [1 ]
Cmil, Maciej [1 ]
Biniek, Wojciech Jerzy [1 ]
Pawlik, Andrzej [1 ]
机构
[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland
[2] Poznan Univ Med Sci, Dept Internal Med, PL-60780 Poznan, Poland
关键词
rheumatoid arthritis; mesenchymal stromal cells; fibroblast-like synoviocytes; macrophages; inflammation; FIBROBLAST-LIKE SYNOVIOCYTES; COLLAGEN-INDUCED ARTHRITIS; UMBILICAL-CORD BLOOD; STEM-CELLS; BONE-MARROW; TNF-ALPHA; MACROPHAGE POLARIZATION; EXTRACELLULAR VESICLES; SYNOVIAL FIBROBLASTS; ADIPOSE-TISSUE;
D O I
10.3390/cells13110915
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.
引用
收藏
页数:17
相关论文
共 50 条
  • [1] The Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in Rheumatoid Arthritis
    Abaszadeh, Amir
    Salehi, Oveis
    Badali, Ahmadreza
    Lavanmardi, Dorsa
    Sarlak, Alireza
    Lotfalian, Azam
    Poudineh, Maryam
    GALEN MEDICAL JOURNAL, 2023, 12
  • [2] Mesenchymal stromal cells for treatment of arthritis
    Swart, J. F.
    Wulffraat, N. M.
    BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2014, 28 (04): : 589 - 603
  • [3] A comprehensive review on the role of mesenchymal stromal/stem cells in the management of rheumatoid arthritis
    Pignatti, Elisa
    Maccaferri, Monia
    Pisciotta, Alessandra
    Carnevale, Gianluca
    Salvarani, Carlo
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2024, 20 (05) : 463 - 484
  • [4] Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications
    Lopez-Santalla, Mercedes
    Fernandez-Perez, Raquel
    Garin, Marina I.
    CELLS, 2020, 9 (08) : 1 - 21
  • [5] Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis
    Okada, A.
    Yamasaki, S.
    Koga, T.
    Kawashiri, S.
    Tamai, M.
    Origuchi, T.
    Nakamura, H.
    Eguchi, K.
    Kawakami, A.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2012, 30 (03) : 332 - 337
  • [6] Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit?
    Bouffi, Carine
    Djouad, Farida
    Mathieu, Marc
    Noel, Daniele
    Jorgensen, Christian
    RHEUMATOLOGY, 2009, 48 (10) : 1185 - 1189
  • [7] Mesenchymal Stromal Cells in Rheumatoid Arthritis: Biological Properties and Clinical Applications
    Kastrinaki, Maria-Christina
    Papadaki, Helen A.
    CURRENT STEM CELL RESEARCH & THERAPY, 2009, 4 (01) : 61 - 69
  • [8] Characteristics of Pooled Wharton's Jelly Mesenchymal Stromal Cells (WJ-MSCs) and their Potential Role in Rheumatoid Arthritis Treatment
    Kannan, Suresh
    Viswanathan, Pachaiyappan
    Gupta, Pawan Kumar
    Kolkundkar, Uday Kumar
    STEM CELL REVIEWS AND REPORTS, 2022, 18 (05) : 1851 - 1864
  • [9] Characteristics of Pooled Wharton’s Jelly Mesenchymal Stromal Cells (WJ-MSCs) and their Potential Role in Rheumatoid Arthritis Treatment
    Suresh Kannan
    Pachaiyappan Viswanathan
    Pawan Kumar Gupta
    Uday Kumar Kolkundkar
    Stem Cell Reviews and Reports, 2022, 18 : 1851 - 1864
  • [10] Role of mesenchymal stem cells secretome in rheumatoid arthritis
    Karhade, Juilee
    Behera, Shubhanath
    Pandey, Garima
    Prasad, Arpita
    Wani, Mohan
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 306 - 306